血脂及脂蛋白与冠心病的相关性分析  

An association study of Lipoprotein and Apolipoprotein levels in the Coronary Heart Disease

作　　者：章菊[1] 叶书来[1] 张昌龙[1] 

机构地区：[1]安徽省立医院检验科,合肥230001

出　　处：《临床输血与检验》2014年第2期152-154,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨血清中脂蛋白、载脂蛋白水平与冠心病(CHD)的关联。方法以健康体检30例为对照组,48例高血压患者和51例CHD患者作为研究对象。分别检测血清中甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)及ApoB、ApoA-I、LP(a)的水平。结果 CHD组与对照组和高血压组比较,HDL-c、ApoA-I、ApoB、ApoB/ApoA-I差别均有统计学意义(均P<0.05),Logistic回归分析提示,HDL-c、ApoA-I、ApoB、ApoB/ApoA-I、LPa均对CHD有显著影响,且HDL-C、LP(a)是CHD独立危险因素;CHD与ApoB、Lp(a)及ApoB/ApoA-I正相关,与HDL-c及ApoA-I负相关。结论共同检测和分析HDL-c、ApoB、ApoB/ApoA-I与Lp(a)水平对冠心病的预测有一定价值。Objective To explore the association of serum lipoprotein and apolipoprotein levels with the coronary artery disease. Methods 48 patients with hypertension and 51 with coronary heart disease（CHD） were recruited for the present research. 30 healthy people were set up as control. The level of TG,TC,HDL-c ,LDL-c and ApoB,ApoA-I, LP （a） were detected. Results There were significant differences of the level of HDL-c,ApoA-I,ApoB,andApoB/ApoA-I（P~ 0.05）between the groups of CHD and hypertension. Among lipid indice, HDL-c,ApoA-I,ApoB,ApoB/ApoA-I,and LPa had a significant effect on CHD. HDL-c and LP（a） were independent risk factors for CHD by using Logistic stepwise re- gression analysis. CHD was positively correlated with ApoB,Lp （a） and ApoB/ApoA-I but negatively with HDL-c and ApoA-I. Conclusions HDL-c,ApoB,ApoB/ApoA-I and Lp（a） are helpful with evaluation of the risk factors of CHD.

关 键 词：冠心病 脂蛋白 载脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]