辽宁地区FoxO1基因rs17446593多态性与2型糖尿病的关系  

Correlation Between FoxO1 Gene rs17446593 Polymorphism and Type 2 Diabetes Mellitus in Li-aoning Province

作　　者：王玉霞[1] 刘迪杰[2] 吴志香[3] 边澈[1] 索琳娜[1] 刘畅[1] 韩玲玲[1] 

机构地区：[1]中国医科大学附属第四医院内分泌科,辽宁沈阳110032 [2]中国医科大学附属第四医院生物治疗科,辽宁沈阳110032 [3]辽宁中医药大学附属医院内分泌科,辽宁沈阳110032

出　　处：《医学临床研究》2014年第3期417-419,共3页Journal of Clinical Research

基　　金：辽宁省科技厅资助项目（2012225019）

摘　　要：【目的】探讨FoxO1基因rs17446593单核苷酸多态性与2型糖尿病（T2DM ）的关系。【方法】395例T2DM患者和366例对照组，用分子量阵列技术（MassARRAY）方法检测FoxO1基因 rs17446593单核苷酸多态性，并用SPSS13．0统计软件进行分析。【结果】FOXO1基因 rs17446593在 T2DM 组GG、GA 型及AA型分别为1．77％、27．09％及71．14％，在对照组GG、GA型及AA型分别为1．64％、20．22％及78．14％（两组间χ2＝5．0460，P ＝0．080）。G等位基因在两组分别为15．32％，及11．75％（两组间χ2＝4．116，P ＝0．042）。【结论】FoxO1基因 rs17446593 G等位基因可能是T2DM的易感基因。[Objective]To explore the correlation between FOXO1 gene rs17446593 polymorphism and type 2 diabetes mellitus（T2DM ） .[Methods] A total of 395 patients with T2DM and 366 control subjects were chosen .MassARRAY method was used to determine FOXO1 gene rs17446593 polymorphism .SPSS13 .0 sta-tistical software was used for the analysis .[Results] The frequencies of genotype GG ,GA and AA of FOXO1 gene rs17446593 in T2DM group were 1 .72% ,27 .09% and 71 .14% ,respectively ,and those in control group were 1 .64% ,20 .22% and 78 .14% ,respectively （χ2 = 5 .0460 ,P =0 .080 between two groups） .The fre-quencies of G allele in two groups were 15 .32% and 11 .75% ,respectively （χ2 =4 .116 ,P =0 .042 between two groups） .[Conclusion]Allele G of FOXO1 gene rs17446593 may be the predisposing gene of T2DM .

关 键 词：糖尿病  2型 多态现象  遗传 辽宁 

分 类 号：R587.1[医药卫生—内分泌]