辽宁地区汉族 IL-1βrs16944基因多态性与2型糖尿病的相关性研究  

Study on the Correlation Between IL-1βRs16944 Gene Polymorphism and Type 2 Diabetes Mel-litus in Han People of Liaoning Province

作　　者：刘畅[1] 王玉霞[1] 吴志香[2] 赵阳[1] 迟希明 

机构地区：[1]中国医科大学附属第四医院内分泌科,辽宁沈阳110032 [2]辽宁中医药大学附属医院内分泌科,辽宁沈阳110032

出　　处：《医学临床研究》2014年第3期426-428,共3页Journal of Clinical Research

基　　金：辽宁省科技厅资助项目（2012225019）

摘　　要：【目的】探讨白介素-1β（IL-1β） rs16944基因多态性与2型糖尿病（T2DM ）的关系。【方法】利用提取基因组DNA及Mass ARRAY 分子量阵列技术对健康对照组人群366人及T2DM患者583例进行基因多态性分析。【结果】IL-1βrs16944基因 AA、AG、GG三种基因型在健康对照组中分布频率分别为22．40％、50．00％、27．60％，在T2DM组中分布频率分别为20．58％、50．09％、29．33％，等位基因 A在健康对照组及T2DM组中分布频率分别为47．40％及45．63％，等位基因G在两组中分布频率分别为52．60％及54．37％，两组各基因型及等位基因型分布相比较无显著性差异（ P ＞0．05）。【结论】IL-1β rs16944基因其多态性可能与辽宁地区T2DM 无关。[Objective] To explore the correlation between interleukin-1β（IL-1β） rs16944 gene polymor-phism and type 2 diabetes mellitus（T2DM ） .[Methods] The extraction genomic DNA and MassARRAY mole-cule weight array were used to analyze the gene polymorphism of IL-1βin healthy control group（n=366） and 583 T2DM patients .[Results]The distribution frequencies of 3 genotypes AA ,AG and GG of IL-1βin healthy control group were 22 .40% ,50 .00% and 27 .60% respectively ,while those inT2DM group were 20 .58% , 50 .09% and 29 .33% , respectively . The distribution frequencies of allele A in healthy control group and T2DM group were 47 .40% and 45 .63% ,respectively .The distribution frequencies of allele G in healthy con-trol group and T2DM group were 52 .60% and 54 .37% ,respectively .There was no significant difference in each genotype and allele genotype between two groups （ P〉0 .05） .[Conclusion]IL-1βrs16944 gene polymor-phism is probably independent of T2DM in Liaoning province .

关 键 词：糖尿病 2型 多态现象 遗传 辽宁 

分 类 号：R587.1[医药卫生—内分泌]