血清白介素-6对糖耐量减低患者动脉粥样硬化的影响  

Effect of Serum Interleukin-6 on Atherosclerosis of Patients with Impaired Glucose Tolerance

作　　者：纪红梅[1] 

机构地区：[1]中国医科大学附属第四医院内分泌科,辽宁沈阳110032

出　　处：《医学临床研究》2014年第3期534-536,共3页Journal of Clinical Research

摘　　要：【目的】探讨糖耐量减低（IG T ）患者颈动脉内膜-中层厚度（IM T ）与白介素-6（IL-6）的关系。【方法】选取IGT患者297例，按颈动脉IMT 分为IMT 正常组（IMT＜1．0mm）103例、IMT增厚组（1．0 mm＜ IMT＜1．3 mm）99例及颈动脉粥样硬化斑块形成组（IMT＞1．3mm）95例，另选100例健康者为对照组，均测定其血清IL-6。【结果】①IGT组血清IL-6显著高于对照组（ P＜0．01），但IM T正常组血清较对照组IL-6相比无明显变化（ P＞0．05）。②IGT组中，IM T增厚者血清IL-6水平显著高于IM T正常组（ P ＜0．01），无论在IM T增厚组或是斑块形成组，IL-6与IM T均呈正相关（ r分别为0．567和0．682， P ＜0．01）。【结论】IG T患者血清IL-6与早期动脉粥样硬化可能有一定的相关性。[Objective] To explore the relationship of carotid intima-media thickness（IMT） with serum inter-leukin-6（IL-6） in patients with impaired glucose tolerance（IGT） .[Methods] According to carotid IMT ,297 IGT patients were divided into normal IMT group（n=103 ,IMT〈1 .0mm） ,IMT thickening group（ n=99 ,1 .0mm〈IMT〈1 .3mm） and carotid atherosclerotic plaque group（ n = 95 ,IMT 〉 1 .3mm） .Other 100 healthy subjects were chosen as control group .Serum IL-6 was determined .[Results] Serum IL-6 in IGT group was higher than that in control group（p〈0 .01） ,but there was no significant difference in IL-6 between normal IMT group and control group（ P〉0 .05） .In IGT group ,serum IL-6 in IM T thickening patients was markedly higher than that in normal IMT group（ P 〈0 .01） .The positive correlation between IL-6 and IMT was shown in both IMT thickening group and atherosclerotic plaque group（r was 0 .567 and 0 .682 respectively ,P〈0 .01） .[Conclusion] Serum IL-6 in IGT patients may have some correlation with early atherosclerosis .

关 键 词：动脉粥样硬化 葡糖耐量试验 白细胞介素6 血液 

分 类 号：R543[医药卫生—心血管疾病]