聚甲酚磺醛盐酸辛可卡因栓直肠刺激性研究  

Experimental study on the rectal irritation of Policresulen Cinchocaine HCl Suppository

作　　者：王海梅[1,2] 邵卿[1,2] 乔红群[1,2] 刘晶[1,2] 

机构地区：[1]江苏省药物研究所 [2]江苏省药物安全性评价中心,江苏南京210009

出　　处：《中国卫生产业》2014年第9期5-6,共2页China Health Industry

摘　　要：目的观察聚甲酚磺醛盐酸辛可卡因栓给予兔直肠后对直肠的刺激性,为临床研究用药提供参考。方法取新西兰兔10只,雌雄各半,按体重随机分为3组,每日给药1次,连续7d,末次给药后24h处死动物,取局部组织,观察有无充血、红肿等现象,同时取直肠进行病理组织学检查。结果动物剖杀时肉眼检查,各组直肠粘膜未见明显异常。病理组织学检查,聚甲酚磺醛盐酸辛可卡因栓直肠给药后,并未引起直肠出现明显的病理改变。结论连续给予聚甲酚磺醛盐酸辛可卡因栓对直肠无刺激性。Objective To evaluate rectal irritation of Policresulen Cinchocaine HC1 Suppository. Methods The rectal irritation of Policresulen Cinchocaine HC1 Suppository was administrated to rabbit, q.d. for 7 d. Pathology histology examine of rectum after stoping remedy 24 hours was made. Results No irritation on rabbites＇ rectum were noted by naked eyes and pathology histology examine. Conclusion Policresulen Cinchocaine HC1 Suppository has no irritation on rabbites＇ rectum.

关 键 词：聚甲酚磺醛盐酸辛可卡因 直肠刺激性 安全性 

分 类 号：R927[医药卫生—药学]