托吡酯抗痫作用的动物实验研究  

The Study of Antiepileptic Effects of Topiramate by Animal Experiment

作　　者：朱祖余[1] 周俐[2] 胡晓[2] 周青[2] 

机构地区：[1]赣南医学院附属医院 [2]赣南医学院基础部,江西赣州341000

出　　处：《赣南医学院学报》2000年第4期312-315,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的 :通过动物实验比较托吡酯 (妥泰 )与传统抗痫药的抗痫作用。方法比较观察三种剂量的托吡酯与 1～ 2种传统抗痫药对最大电休克发作试验 ,戊四唑发作阈值试验 ,印防已毒素发作试验 ,士的宁发作试验的作用。结果 :大中剂量的托吡酯对最大电休克发作试验、戊四唑发作阈值试验、印防已毒素发作试验有效 ,但效果不如传统药物。结论 :托吡酯是一种作用广泛的抗痫新药 ,但作为单独用药或首选用药还需临床进一步论证。Objective:To compare the antiepileptic effects of Topiramate and traditional antiepileptic drugs by experiment with animals. Method Observe and compare Topiramate of three kinds of doses with 1-2kinds of traditional antiepileptic drugs and their effects on manimal eletroshock seizure test,Metrazol seizure threshold test , Picrotoxin seizure test and Strychine seizure test . Result largeand medium doses of Topiramate were effective , but not so effective as traditional antiepileptic drugs.Therefore, whether it can be used alone or as the first choice needs further clinical proof. [

关 键 词：托吡酯 抗痫作用 动物实验 药理 

分 类 号：R971.6[医药卫生—药品]