铜针电栓塞血管的机制研究  

MECHANISM STUDY OF ELECTROTHROMBOSIS BY COPPER NEEDLE

作　　者：李东[1] 贾铁利[2] 秦荣生[1] 邓德宁[3] 李建宁[1] 

机构地区：[1]北京大学第三医院成形外科,北京100083 [2]空军总医院整形外科 [3]北京大学医学部物理系

出　　处：《中国修复重建外科杂志》2001年第1期42-45,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　研究铜针电栓塞血管的机制 ,为临床治疗提供参考依据。方法　以体外实验和大鼠体内实验为模型 ,用电子物理学、原子光谱吸收法、组织学和组织化学等方法研究铜针通电后血栓形成的机制和条件。结果　铜针通电后有大量铜离子解离及红细胞聚集 ,在一定电压和通电时间作用下血管内形成稳定的血栓。结论铜离子解离和红细胞聚集是铜针电栓塞血管的主要机制 ,稳压直流电 4V和 17.5分钟的通电时间为血栓形成的安全有效条件。Objective To investigate the mechanism of electrothrombosis by copper needle, in order to supply the referential data for clinical treatment of vessel deformity. Methods The mechanism and condition of thrombus formation by copper needle were studied in vivo and in vitro using electrophysics, atom absorption spectrophtometry, histological, and histochemical methods. Results Great deal of copper ion was dissociated, and agglutination of red blood cells(RBC) in blood could be observed in vitro after the current applied by copper needles. Formation of stable thrombus was related to voltage and time of application of electric current. Conclusion Dissociation of copper ion and agglutination of RBC are the basic principle of electrothrombosis with copper needle. A 4V direct current and 17.5 minutes are the safe and effective conditions for thrombus formation in the blood vessels.

关 键 词：铜针 电栓塞 血管 血栓 

分 类 号：R543[医药卫生—心血管疾病]