连花清瘟胶囊辅治急性上呼吸道感染的疗效观察及其对IFN-γ的影响  

Effect of Lianhuaqingwen capsule on acute upper respiratory infection and their impact on the IFN-γ

作　　者：魏梅[1] 宋煜勋[1] 周红[2] 

机构地区：[1]首都医科大学电力教学医院/北京电力医院呼吸内科,100073 [2]首都医科大学电力教学医院/北京电力医院健康管理中心,100073

出　　处：《疑难病杂志》2014年第4期345-348,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的评价连花清瘟胶囊治疗急性上呼吸道感染临床疗效及其对干扰素γ(IFN-γ)的影响。方法急性上呼吸道感染患者203例随机分为2组,治疗组101例口服连花清瘟胶囊,对照组102例给予阿奇霉素片。观察比较2组的疗效,同时2组患者各随机抽取20例于治疗前后各抽取静脉血,应用ELISA试剂盒检测其血清IFN-γ的浓度。结果治疗组在总体疗效有效率,体温下降有效率和各临床症状体征改善率方面均高于对照组,2组患者在患病后其血清IFN-γ含量均明显升高,治疗后明显下降,且治疗组下降更明显,均具有统计学意义(P<0.05)。2组患者治疗后白细胞总数和中性粒细胞比例均显著下降(P<0.05),但2组间比较,差异均无统计学意义(P>0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论连花清瘟胶囊可缓解急性上呼吸道感染的各种临床症状,并有一定的抗炎抗病毒作用。Objective To evaluate the efficacy and safety of Lianhuaqingwen capsule in the treatment of acute upper respiratory infection and observe the effect on interferon gamma （ IFN-γ） of patients .Methods 203 cases of acute upper re-spiratory tract infection were randomly divided into two groups , treatment group of 101 cases （oral Lianhuaqingwen capsules）, 102 cases in the control group given azithromycin tablets .To compare the efficacy of two groups , while the two groups were each randomly selected 20 cases of venous blood before and after each treatment , the application of ELISA kits to detect the concentration of serum IFN-γ.Results Overall efficacy in the treatment group effectiveness , efficiency and the temperature drops various clinical symptoms and signs of improvement rates were higher , two groups of patients in the prevalence of serum IFNγlevels were significantly higher , decreased significantly after treatment , with the treatment group decreased more signifi-cantly （ P 〈0.05）.After treatment, two group patients＆#39;WBC and neutrophil percentage were significantly decreased （ P 〈0.05）, but between the two groups , the difference was not statistically significant （ P 〉0.05）.The incidence of adverse re-actions was not significant difference （ P 〉0.05 ） .Conclusion Lianhuaqingwen capsule can relieve a variety of clinical symptoms of acute upper respiratory tract infection , and have some anti-inflammatory antiviral activity .

关 键 词：连花清瘟胶囊 上呼吸道感染 急性 IFN-Γ IFN-Γ 

分 类 号：R259[医药卫生—中西医结合]