金纳米笼胶囊的制备及其在肿瘤细胞药物投放中的应用  

Preparation and Application in Tumor Cells' Drug Delivery of Gold Nanocapsule

作　　者：钟华[1] 许海平[1] 张慧[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,青岛266042

出　　处：《分析化学》2014年第4期475-481,共7页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No 21305073)资助项目~~

摘　　要：纳米胶囊以其独特的优点,在生物医学领域中应用广泛。本工作介绍了一种以金纳米笼为核心,内部装载抗癌药物盐酸阿霉素(DOX),以功能化的DNA纳米材料为外壳并封锁笼口的新型纳米胶囊。这一纳米胶囊集细胞荧光成像、药物靶向投送功能于一体,可通过荧光显微镜识别靶细胞(本实验以人类B淋巴瘤细胞-Ramos细胞为研究对象),同时释放药物作用于靶细胞,诱导靶细胞凋亡。该纳米胶囊的研究为肿瘤细胞的诊断及靶向药物研究领域提供了一定的理论研究依据。Abstract Nanocapsules are widely used in the biomedical field because of its unique features. A new nanocapsule was prepared by using gold cage as the core, anticancer drug doxorubicin hydrochloride （DOX） as the internal filler, and functionalized DNA nanomaterials as the shell. The mouth of the cage was blocked by the functionalized DNA nanomaterials. The nanocapsule can be used for the cell detection and drug delivery. The target ceils （Ramos cells） can be detected by fluorescence microscope when the drug that can act on target cells and lead to cell death was released. The nanocapsule provides a new approach for the diagnosis and treatment of tumor cells.

关 键 词：金纳米笼 淋巴瘤细胞 脱氧核糖核酸适体 药物释放 荧光显微镜 

分 类 号：TQ460.1[化学工程—制药化工]