慢性阻塞性肺病急性加重期患者血清中IL-32、CRP的变化及其意义  

Clinical Efficacy of the Changes of Serum IL-32 and CRP in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：范世明[1] 郝青林[2] 任燕[1] 

机构地区：[1]宜宾市第一人民医院呼吸内科儿科,四川宜宾644000 [2]昆明医科大学第一附属医院呼吸内一科,云南昆明650032

出　　处：《四川医学》2014年第4期450-451,共2页Sichuan Medical Journal

摘　　要：目的探讨慢性阻塞性肺病急性加重期(AECOPD)患者血清IL-32和CRP的含量变化及临床意义。方法分别检测33例AECOPD患者治疗前后及20例健康体检者外周血,采用双抗体ELISA法测定IL-32,免疫比浊法测定CRP。结果 AECOPD患者治疗前血清IL-32为(126.44±86.69)pg/mL,CRP水平为(40.8±21.1)mg/L,明显高于治疗后(均P<0.05);且治疗前血清IL-32、CRP水平较正常对照组显著增高(P<0.05);治疗后血清IL-32、CRP水平仍高于正常对照组(P<0.05)。结论动态监测血清IL-32、CRP变化对于评价AECOPD患者病情具有一定的临床意义。Objective To study the implication of interleukin-32（IL-32）and C-reactive protein（CRP）in the exacerbation of chronic obstructive pulmonary diseases（AECOPD）. Methods The serum was sampled and prepared from 33 cases of COPD patients with acute exacerbation before and after two weeks therapy and 20 normal controls. Serum level of IL-32 was detected by ELISA and CRP by immunoturbidimetry method. Results The level of IL-32 in AECOPD Is significantly higher than that after therapy（P〈0. 05）and lower than that in control group（P〈0. 05）. The level of CRP in acute exacerbation is significantly higher than that in control group（P〈0. 05）. Conclusion IL-32 and CRP are involved in the acute inflammation in COPD which may be indices of infection in COPD patients.

关 键 词：慢性阻塞性肺疾病急性加重期 白细胞介素-32 C反应蛋白 INTERLEUKIN-32 

分 类 号：R563.9[医药卫生—呼吸系统]