脂联素配合微创清除术在冠心病患者中的诊疗意义及其与炎症因子相关性分析  

The diagnostic and treatment significance of adiponectin in combination with micro-cleaning operation in coronary artery disease and its relationship with inflammatory factors

作　　者：胡宗华 王春梅 

机构地区：[1]湖北省宜城市人民医院心血管内科,宜城市441400

出　　处：《微创医学》2014年第2期156-159,共4页Journal of Minimally Invasive Medicine

摘　　要：目的比较冠心病及正常对照组血液中脂联素及炎症因子的水平差异,分析脂联素与炎症因子的相关性,评估脂联素配合微创清除术在冠心病患者中的诊疗意义。方法选择2011年7月至2013年7月在该院接受治疗的80例冠心病患者(观察组),另选取70例健康体检者作为正常对照组,分析两组脂联素及炎症因子的差异及其相关性。并对30例行微创清除手术(介入)和10例行开胸手术治疗的患者进行脂联素与预后的分析。结果观察组与对照组在性别比例、年龄、体质指数(BMI)和空腹血糖上比较,差异均无统计学意义(P>0.05),而观察组总胆固醇和甘油三酯高于对照组(P<0.05)。观察组炎症指标(hs-CRP、TNF-α和IL-6)均明显高于正常对照组(P<0.05),而脂联素低于对照组(P<0.05),观察组脂联素水平与CRP(r=-0.412,P<0.01)、TNF-α(r=-0.382,P<0.01)和IL-6(r=-0.321,P<0.01)均呈负相关关系。微创清除介入术患者的住院时间和费用均小于开胸手术组,且微创术后脂联素水平与住院时间(r=-0.335,P=0.023)和住院费用(r=-0.415,P=0.018)均呈负相关关系。结论冠心病患者的脂质、炎症因子水平明显升高,而脂联素水平却下降,并且脂联素与炎症因子呈明显的负相关关系。微创术后脂联素水平与住院时间和住院费用负相关。Objective To compare the difference in adiponectin and inflammation factors between coronary disease and the normal, analyze the correlation between adiponectin and inflammation factors, and estimate the diagnostic and treatment significance of adiponectin in combination with micro-cleaning operation. Methods Eighty coronary disease patients（ treatment group） treated at our hospital from 2011 to 2013 and 70 healthy volunteers as normal control group were enrolled, and their difference and correlation in adiponeetin and inflammations factor were analyzed. Another 30 cases of micro-cleaning operation and 10 cases of thoractomy for coronary disease were compared in terms of adiponectin and prognosis. Results There was no statistical difference in the gender, age, BMI, or fasting blood-glucose between the treatment group and the control group. Compared to the control group, the treatment group had higher levels of total cholesterol, triglyceride, and inflammation factors （IL-6, TNF-αand hs-CRP ）, and lower level of adiponectin （P 〈 0.05）. Negative linear correlations between adiponeetin and inflammation factors were detected in the treatment group （CRP, r = -0.412, P 〈 0.01; TNF - ot,r = - 0. 382, P 〈 0.01 ; IL-6 , r = - 0. 321, P 〈0.01 ）. Micro-cleaning operation patients had less hospital stay time and cost than the thoractomy pa- tients, and its adiponeetin level was in negative linear correlation with hospital stay time （ r = - O. 335, P=0.023） and hospital cost（r= -0.415, P =0.018）. Conclusions In patients with coronary artery disease, levels of the lipid and inflammation factors increase, while adiponeetin level decreases, and negative linear correlation between adiponectin and inflammation factors exists. In addition, adiponectin levels aftermicro-cleaning operation is negatively correlated with both hospital stay time and cost.

关 键 词：冠心病 脂联素 炎症因子 微创手术 开胸手术 

分 类 号：R541.4[医药卫生—心血管疾病]