二硫化碳接触对粘胶工人血清铜、锌和硒含量的影响  

The Effects of the Exposure to CS_(2) on Serum Copper,Serum Zinc and Serum Selenium of Workers in the Viscose Rayon Factory

作　　者：孔丹莉[1] 毕勇毅[2] 文冠华[2] 谭晓东[2] 陶宁[2] 王福元[2] 汪春红[2] 王红[2] 

机构地区：[1]广东医学院预防医学教研室,湛江524023 [2]湖北医科大学卫生学教研室

出　　处：《中国公共卫生》2001年第1期55-57,共3页Chinese Journal of Public Health

基　　金：比利时ABOS基金资助项目(ABOS-13V1346);湖北省教委重点科研基金资助项目!(97A058)

摘　　要：目的　探讨CS2 接触与血清微量元素铜、锌、硒之间的关系 ,为CS2 接触致心血管系统疾病的毒作用机理提供依据。方法　选择某化纤厂纺丝车间年龄在 45岁以下 ,接触CS2 5年以上 76名CS2 作业工作为接触组 ;在同一工厂棉浆车间选择曾经接触过CS2 但现在已停止CS2 接触 5年以上的 33名工人作为干预组 ;从未接触过CS2 的 2 3名工人作为对照组进行流行病学横断面调查。结果　接触组SCu、SZn和SSe含量均低于对照组 (P =0 0 0 0 1) ;多元逐步回归分析进一步显示 ,CS2 对SCu、SZn和SSe含量均有负贡献 (偏回归系数 β分别为 -10 4173,- 8 973和 - 15 5 0 98)。结论　提示CS2 接触能降低血清铜、锌。Objective To explore the relation between CS 2 exposure and the trace elements of serum copper,serum zinc,serum selenium,provide the basis for the mechanism of toxicity effects of CS 2 on cardiovascular system disease.Methods In filature workshop of a viscose rayon factory we selected 76 workers with age below 45 years old and touchtime to CS 2 beyond 5 years as exposure group;In cotton plasm workshop of the same factory selected 33 workers who once touched CS 2 but now have been kept away from CS 2 more than 5 years as intervention group;and selected 23 workers who had never touched CS 2 as control one,and the epidemiological cross sectional investigation was carried out.Results SCu,SZn and S Se of exposure group were all lower than control one (P=0.001).In multivariable stepwise regression,we discovered that exposure to CS 2 caused negative contributions on SCu,SZn,and SSe(partial regression coefficients β are separately -10.417,-8.9735 and -15.5098).Conclusion The results suggested CS 2 exposure could reduce the levels of Scu,SZn and S Se .

关 键 词：二硫化碳 血清铜 血清锌 血清硒 

分 类 号：R135.1[医药卫生—劳动卫生] R446.112[医药卫生—公共卫生与预防医学]