瘤果黑种草子挥发油抗炎、祛痰药理作用  

Study on the anti-inflammatory and expectorant effects of volatile oil from Nigella Glandulif-era

作　　者：耿东升[1] 王雪飞[2] 陈雪莲[1] 

机构地区：[1]新疆军区联勤部药品仪器检验所,新疆乌鲁木齐830063 [2]新疆医科大学,新疆乌鲁木齐830054

出　　处：《中国医院药学杂志》2014年第8期605-607,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助项目(编号:30960512)

摘　　要：目的:首次研究瘤果黑种草子挥发油的抗炎及祛痰作用。方法:采用角叉菜胶致小鼠足跖肿胀、大鼠棉球肉芽肿实验观察瘤果黑种草子挥发油(VONG)抗炎作用;小鼠气管酚红排泌法、家兔促进气管纤毛黏液流实验观察其祛痰作用。结果:瘤果黑种草子挥发油能明显抑制小鼠足跖肿胀度及大鼠棉球肉芽肿,促进气管酚红排泌量,增加家兔气管纤毛黏液流运动速度,与对照组比较,差异具有极显著统计学意义(P<0.01)。结论:瘤果黑种草子挥发油具有一定的抗炎、祛痰作用。OBJECTIVE To investigate the anti-inflammatory and expectorant effects of volatile oil from Nigella glandulifera （VONG） for the first time. METHODS The carrageenan-induced paw edema in mice and cotton ball induced granuloma exper- iments were employed to evaluate the anti-inflammatory effect; a mouse model of phenol red test and the rabbit tracheal ciliary mucus flow promotion experiments were employed to evaluate the expectorant effect. RESULTS The experimental results showed that the different dose group of VONG could significantly inhibit carrageenan-induced mouse paw swelling degree and the hyperplasia of granulation tissue in rats（P〈0. 01）; increase phenol red excretion in mice and rabbit tracheal ciliary mucus flow velocity （P〈0.01）. CONCLUSION The results indicated that VONG has some anti-inflammatory and expectorant activ- ities.

关 键 词：瘤果黑种草子 挥发油 抗炎 祛痰 

分 类 号：R285.5[医药卫生—中药学]