依折麦布联合瑞舒伐他汀治疗高脂血症疗效观察  

The effect of ezetimibe combined with rosuvastatin in the treatment of patients with hyperlipidemia

作　　者：李丽燕[1] 李雷[1] 杨荣礼[1] 

机构地区：[1]徐州医学院附属医院老年病科,江苏徐州221000

出　　处：《蚌埠医学院学报》2014年第4期451-453,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨依折麦布联合瑞舒伐他汀治疗高脂血症的疗效。方法:将76例高脂血症患者分为观察组和对照组各38例,对照组患者采用瑞舒伐他汀治疗,观察组患者在对照组治疗的基础上加用依折麦布治疗。比较2组患者血脂指标总胆固醇降低值、低密度脂蛋白胆固醇降低值,丙氨酸氨基转移酶(ALT)和肌酸激酶(CK)升高值。结果:观察组总胆固醇和低密度脂蛋白胆固醇降低值均大于对照组(P<0.01);观察组ALT、CK升高值均大于对照组(P<0.01),而天冬氨酸氨基转移酶升高值低于对照组(P<0.01)。结论:依折麦布联合瑞舒伐他汀治疗高脂血症能更有效地降低血脂水平,同时需要监测ALT及CK变化。Objective： To observe the effect of ezetimibe combined with rosuvastatin in the treatment of patients with hypercholesterolemia. Methods：Seventy-six patients with hypercholesterolemia were randomly divided into two groups：experimental group （n = 38, treated with ezetimibe and rosuvastatin） and control group （n = 38, treated with rosuvastatin alone, 10 mg/d）. The lipid levels of all patients were assessed after three months treatment. Results： The cholesterol and low-density lipoprotein levels in experimental group were decreased more remarkably than those in control group（ P 〈 0. 01 ）. In contrary, the alanine aminotransferase and creatine kinase levels in experimental group were increased more remarkably than those in control group（ P 〈 0. 01 ）. The increase of aspartate aminotransferase level in experimental group was lower than that in control group （ P 〈 0. 01 ）. Conclusions ： Ezetimibe combined with rosuvastatin can decrease lipid levels than rosuvastatin only when treated patients with hypercholesterolemia, but it need to measure the changes of alanine aminotransferase and creatine kinase levels.

关 键 词：高脂血症 依折麦布 瑞舒伐他汀 

分 类 号：R589.21[医药卫生—内分泌]