严重烧伤病人早期血浆内皮素变化与心肌损害关系的初步探讨  

A Preliminary Study of the Relationship between Plasma Endothelin Level and Myocardial Damage at the Early Stage of Severe Burn

作　　者：钟克勤[1] 马恩庆[1] 

机构地区：[1]中南大学医学院湘雅医院烧伤科,湖南长沙410008

出　　处：《中国烧伤创疡杂志》2001年第1期42-44,共3页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的：探讨血浆内皮素 (ET)变化与烧伤早期心肌损害的关系。方法：采用放免法检测 5例严重烧伤病人烧伤早期血浆 ET和 ASCA仪测定血浆肌酸激酶同工酶 (CK-MB)。结果：伤后 12h血浆 ET（ 106.0± 1.6 pg/ml， n=5）较正常人组（ 47.6± 3.4 pg/ml， n=8）明显升高。血浆 CK-MB在伤后明显升高。相关分析显示， ET升高与 CK-MB呈高度正相关。结论：血浆 ET升高可能参与了烧伤早期的心肌损害。Objective: To study the effect of plasma endothelin (ET) level on myocardial injury of severely burned patients. Method: Plasma ET level was determined by radio-immunoassay and plasma levels of CK-MB by automatic serum biochemical assay. Result: Plasma ET level increased significantly 12 hr post burn as compared with normal persons (P<0.01), plasma CK-MB increased significantly within first 24 hr post burn. Plasma ET level was positive correlated to CK-MB level. Conclusion: The results suggested that elevated plasma ET level may be involved in the damage of myocardium in the early stage of severe burn.

关 键 词：内皮素 肌酸激酶同工酶 烧伤 心肌损害 

分 类 号：R644[医药卫生—外科学]