脾不统血证血小板聚集功能的研究  

Study on Platelet Aggregation Function of Paients with Failure of Spleen to Control Circulating Blood Syndrome

作　　者：沈迪[1] 沈霖[1] 王爱莲[1] 杨锐[1] 杨焰[1] 魏文宁[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内科,武汉430022

出　　处：《中国中西医结合消化杂志》2001年第1期5-7,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金资助项目 (No .39370 32 2 )

摘　　要：目的 :探索脾不统血证发病机制与血小板聚集功能的关系。方法 :中医诊断脾虚证伴有慢性多部位反复出血患者 ,选择其中血小板计数正常、凝血像无明显异常者共 146例 ,采用Chronolog血小板聚集仪检测患者血小板聚集率。结果 :应用 3种常用诱聚剂诱导患者血小板出现聚集缺陷者 76例 ,其缺陷率占 5 2 0 5 % ;对照组为脾虚证无出血者 82例 ,其血小板聚集缺陷者 2 1例 ,占 2 5 6 1%。两组之间差异有非常显著性意义 (χ2 =14 6 3,P <0 0 1)。结论 :脾不统血证慢性反复出血的发病机制 ,半数病例可能与血小板聚集功能缺陷有关 ,但其确切病机有待进一步研究。Objective:To explore the relationship between the pathogenesis of syndrome of failure of spleen to control circulating blood and the function of platelet aggregation.Methods:146 cases of 'spleen deficiency' associated with chronic repeated multiple focal bleedings and with normal platelet count and coagulogram were selected,their platelet aggregation rates were detected by Chronolog blood platelet agglutometer.Results:There were 76 cases making a defect of platelet aggregation response to ADP,platelet activating factor and/or arachidonic acid induced,the abnormality was about 52.05%.And 82 cases of 'spleen deficiency' without bleeding for control,the platelet aggregation defect about 25.61%.The difference between two groups was significant(P< 0.01 ).Conclusion:The results suggested that more than half the number of patients with failure of spleen to control circulating blood syndrome were related to platelet aggregation defects.

关 键 词：脾不统血 脾虚证 血小板聚集 

分 类 号：R256.39[医药卫生—中医内科学]