任意皮瓣掀起后内皮素、一氧化氮动态变化与皮瓣微循环血量的关系  

INFLUENCE OF DYNAMIC CHANGES OF ENDOTHELIN AND NITRIC OXIDE ON BLOOD MI-CROCIRCULATION IN RANDOM FLAP IN PIGS

作　　者：晏泽[1] 肖能坎[1] 肖添有[1] 胡俊勇[1] 陈兵[1] 陈伯华[1] 王晋煌[1] 

机构地区：[1]解放军第一军医大学珠江医院整形烧伤外科,广州510282

出　　处：《西南国防医药》2001年第1期7-10,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:探讨任意皮瓣掀起后血管活性因子内皮素(ET)、一氧化氮(NO)动态变化与皮瓣微循环血量的关系。方法:在猪背部两侧制备任意皮瓣,术前取背部皮肤全层测定ET、NO含量,术后取皮瓣中部皮肤全层测定;术前应用激光多谱勒血流测定仪测量背部皮肤微循环血量,术后24h持续监测皮瓣中部皮瓣微循环血量。结果:皮瓣ET、NO含量在术后1h开始明显上升,NO 3h达到峰值,ET 6h达到。皮瓣掀起后微循环血量急剧下降,1h左右下降至最低。皮瓣掀起后1、3h组织中ET含量与皮瓣微循环血量成显著负相关(γ=0.776,P<0.01)。NO含量与皮瓣微循环血量成显著正相关(γ=0.853,P<0.01)。结论:皮瓣掀起初期ET、NO动态变化与皮瓣微循环血量密切相关。Objective: Six piglets were used to learn the influence of endothelin (ET) and nitric oxide (NO) on blood microcirculation in random flap. 36 random flaps were elevated on the backs of these animals. Method: The micro-circulatory blood flow in these flaps was continuously measured with laser Doppler velocimety at different times. Result; It was found that both ET and NO concentrations in the flaps increased significantly after elevation Ih. NO value reached the peak at 3h and ET did at 6h. But the microcirculatory blood flow decreased greatly after the elevation and reached the lowest point at Ih. There was a negative correlation between ET concentration in the flap and flap's micro-circulatory blood flow (γ=-0. 776,P<0. 01), and a positive correlation between NO concentration and the flow (γ= 0. 853,P<0. 01). Conclusion: It is concluded that the changes of ET and NO levels in the flaps during early elevation stage play an important role in the flap's blood microcirculation.

关 键 词：内皮素 一氧化氮 任意皮瓣 微循环血量 

分 类 号：R644.05[医药卫生—外科学]