系统性红斑狼疮多因子遗传的通径分析  

Poth analysis in mltifacterial heridity with systemetic lupus erythematosus.

作　　者：孟炜[1] 江峰[1] 沈福民[1] 胡应[1] 秦万章[2] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室原,上海医科大学公共卫生学院200032 [2]复旦大学附属中山医院原,上海医科大学附属中山医院200032

出　　处：《中国优生与遗传杂志》2001年第1期9-11,共3页Chinese Journal of Birth Health & Heredity

摘　　要：本文应用ATRIBUTE软件对 2 15例先证者及其核心家系进行了通径分析 ,以探讨SLE可能的遗传模式。结果表明 ,与一般模型比较 ,H =0和 (H =0 ,C =0 )的假设被拒绝 ,提示SLE不符合单基因遗传 ,存在多基因遗传模式。本病可能是一多因子疾病 ,遗传度为 49.9%。Jn this articl,path anlaysis was performed with their nuclear families through 215 probands using ATRIBUTE software,so as to probe the probable genetic mode of systemic lupus erythematosus(SLE),The result suggested that anlysis of data from the samples allowed rejection of the hypotheses of (H=0,C=0)as well as (H=0),as compared with the general model indicating that SLE disagreed to single genetic model,and recepting a multifactorial genetic mode.SLE probably is a multifactorial disease,with its heredity being 49.9%.

关 键 词：系统性红斑狼疮 通径分析 遗传度 多基因遗传模式 

分 类 号：R593.241[医药卫生—内科学]