黄芩苷固体分散体的制备及其体外溶出行为考察  

Preparation of Baicalin Solid Dispersions and Investigation of Its Dissolution Behavior

作　　者：谈唯[1] 丁冬梅[1] 张振海[1] 孙娥[1] 贾晓斌[1] 

机构地区：[1]江苏省中医药研究院,国家中医药管理局中药释药系统重点研究室,南京210028

出　　处：《中国实验方剂学杂志》2014年第9期12-15,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省社会发展科技支撑计划项目(BE2010756);江苏省中医药科技项目(LZ11065)

摘　　要：目的：考察不同溶出条件对黄芩苷固体分散体溶出特性的影响.方法：采用溶剂蒸发法制备黄芩苷-聚乙二醇（PEG） 6000固体分散体,利用差示扫描量热法及X-射线衍射法鉴别固体分散体的形成,考察不同溶出条件对其体外溶出特性的影响.结果：黄芩苷以非晶形态分散在固体分散体中;纯水介质中15 min时释放65％,之后释放平缓增加,330 min时释放＞70％;人工胃液中,15 min释放30％,330 min约释放56％;在模拟胃肠道介质中,胃内环境中释放较慢,15～120 min释放30％ ～54％,小肠环境中释放较快,120 ～330 min释放54％ ～69％.结论：黄芩苷-PEG6000固体分散体在不同溶出方法中的溶出性质存在差异,动态溶出介质值得推广应用.Objective：To investigate effectsof different dissolution conditions on dissolution characteristics of baicalin solid dispersions.Method：Baicalin-PEG6000 solid dispersions was prepared by solvent evaporation method,DSC and X-ray diffraction method were adopted to identify its formation,and effects of different conditions on its in vitro dissolution were investigated.Result：Baicalin was in amorphous form dispersed in solid dispersions; Stripping properties of baicalin solid dispersions in different kinds of stripping method were different; In pure water medium,release of baicalin was 65％ in 15 min,then release slow increased,released more than 70％ in 330 min; In artificial gastric juice,it released 30％ in 15 min and 56％ in 330 min; In simulated gastrointestinal medium,it released slowly in the stomach environment （released 30％-54％ in 15-120 min） and released quickly in the small intestine environment （released 54％-69％ in 120-330 min）.Conclusion：Dissolution properties of baicalin-PEG6000 solid dispersions in different dissolution methods were different,dynamic dissolution medium should be widely applied.

关 键 词：黄芩苷 聚乙二醇6000 固体分散体 动态溶出介质 体外溶出试验 

分 类 号：R283.6[医药卫生—中药学]