环境雌激素双酚A与多囊卵巢综合征的相关性研究  

Study on the correlation between environmental estrogen bisphenol A and polycystic ovary syndrome

作　　者：周飞飞[1] 谭季春[1] 王莎莎[1] 赵姗姗[1] 郝博[1] 李雅璇[1] 李小妮[1] 丛集美[1] 

机构地区：[1]中国医科大学附属盛京医院,辽宁沈阳110000

出　　处：《中国妇幼保健》2014年第13期2049-2051,共3页Maternal and Child Health Care of China

基　　金：辽宁省科技计划项目〔2009225007-6〕

摘　　要：目的:初步探讨双酚A与多囊卵巢综合征发病机制的关系。方法:采用酶联免疫吸附(ELISA)技术测定109例多囊卵巢综合征患者及104例正常对照组患者血清中的双酚A(BPA)含量及激素水平,采用SPSS 17.0软件进行统计学分析。结果:与对照组相比,PCOS组的LH、LH/FSH、T含量显著高于对照组(P<0.001),PCOS组BPA浓度为(2 874.40±78.70)ng/L,对照组BPA浓度为(1 866.53±282.71)ng/L,两组BPA浓度比较有统计学差异(P<0.001),雄激素和BPA之间有显著的相关性(r=0.38,P<0.001)。结论:在PCOS病理生理过程中BPA是可能的内分泌干扰物,雄激素和BPA之间呈正相关。Objective： To preliminarily explore the relationship between bisphenol A and pathogenesis of polycystic ovary syndrome （PCOS） . Methods： EL1SA was used to detect serum bisphenol A contents and hormones levels in 109 cases with PCOS （PCOS group） and 104 cases without PCOS （control group） ; the data were analyzed statistically on software SPSS 17.0. Results： Compared with control group, the levels of luteinizing hormone （LH） , LH/follicle - stimulating hormone （FSH） and testosterone （T） in PCOS group were statisti- cally significantly higher than those in control group （P 〈 0.001 ） ; the concentrations of bisphenol A in PCOS group and control group were （2 874. 40 ±78.70） ng/L and （ 1 866. 53 ±282. 71 ） ng/L, respectively, there was statistically significant difference between the two groups （ P 〈 0. 001 ）, there was a significant correlation between androgen and bisphenol A （ r = 0. 38, P 〈 0. 001 ） . Conclusion ： In the patho- genesis of PCOS, bisphenol A is a possible endocrine disruptor, and there is a positive correlation between androgen and bisphenol A.

关 键 词：双酚A 多囊卵巢综合征 激素 

分 类 号：R711.75[医药卫生—妇产科学]