血清阴性脊柱关节病与HLA-DRB1基因相关性研究  

Study of Association between Seronegative Spondyloarthropathy and HLA-DRB1 Genes

作　　者：杨珏琴[1] 姚芳娟[1] 葛瑜[1] 范丽安[1] 

机构地区：[1]上海第二医科大学上海市免疫学研究所,上海200025

出　　处：《上海免疫学杂志》2001年第1期33-35,共3页Shanghai Journal of Immunology

基　　金：上海市教委和上海市联合利华发展基金

摘　　要：为探讨HLA DRB1基因与血清阴性脊柱关节病 (SpA )的相关性 ,我们采用PCR/SSO方法对上海地区 2 14例SpA患者及 15 0例随机正常对照、 13例B2 7阳性正常对照进行HLA DRB1基因分型。结果发现HLA DR12在病人组中明显高与正常对照组及B2 7阳性正常对照组 ,Pc =0 0 0 19,RR =1 988。DR6明显低于B2 7阳性对照组 ,P <0 0 0 5 ;DR6在B2 7阳性对照组中高于随机对照组 ,P <0 0 0 5。提示 ,上海地区SpA患者其DR12基因与B2 7之间可能存在连锁不平衡 ,并可能增加对SpA的易感性 ;而DR6则可能对SpA的易感有保护作用。To investigate the association between seronegative spondyloarthropathies(SpA) and HLA DRB1 gene 214 B27 positive patients with SpA in Shanghai area and 13 cases of B27 positive controls and 150 normal individuals were genotyped for HLA DRB1 by PCR/SSO method The results showed that frequency of HLA DR12 gene was significantly increased in patients in comparison with normal controls and B27 positive control groups, Pc=0 0019, RR =1 988 The frequency of DR6 gene was significantly decreased in patients It suggests that HLA DR12 may be a susceptibility gene to SpA in Shanghai area and DR6 may play a protective effect to SpA.

关 键 词：血清阴性脊术关节病 HLA-DRB1基因 HLA-B27 

分 类 号：R684[医药卫生—骨科学]