氯化亚锡还原法合成4'-氨基黄体酮类苯亚甲基衍生物  

Synthesis of 4'-Aminobenzylidene Derivative of Progesterone with Tin( Ⅱ) Chloride as the Reducing Agent

作　　者：范宁娟[1] 王长如[1] 汤江江[1] 高锦明[1] 

机构地区：[1]西北农林科技大学理学院,杨凌712100

出　　处：《应用化学》2014年第5期520-523,共4页Chinese Journal of Applied Chemistry

基　　金：中央高校基本科研业务费专项资金(QN2012047)~~

摘　　要：以黄体酮为原料,合成了4'-硝基苯亚甲基衍生物3,将其在SnCl2·2H2O/HCl体系中还原后得4'-氨基苯亚甲基衍生物4。还原时以乙酸乙酯为溶剂,还原剂SnCl2为底物5倍化学计量时产率达74%,为甾类氨基衍生物的合成提供了一种便利方法。The 4＇-nitrobenzylidene derivative 3 prepared from progesterone was reduced by SnC12 ·2H2O/HCl to obtain 4＇-aminobenzylidene derivative 4. When ethyl acetate was used as the solvent and five equivalents of SnC12 was used as the reducing agent, the yield was up to 74%, which provides a convenient route to synthesize amino-modified steroidal derivatives.

关 键 词：黄体酮 苯亚甲基甾体衍生物 氯化亚锡 

分 类 号：O625[理学—有机化学]