不同品种威灵仙水煎液外用对大鼠痔疮、佐剂性关节炎模型的影响  

Anti-inflammatory Effects of Decoctions of Different Varieties Clematidis Radix et Rhizoma by External Use on Hemorrhoid and Adjuvant-induced Arthritis Rat Model

作　　者：于舒雁[1] 魏荣锐[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中国现代应用药学》2014年第4期391-397,共7页Chinese Journal of Modern Applied Pharmacy

基　　金：国家"十一五"支撑计划(2008BAI53B09);高校科技创新团队(2012IRTSTHN011)

摘　　要：目的通过对威灵仙的外用实验研究,探索其对痔疮和佐剂性关节炎的治疗作用。方法观察3种威灵仙水煎液外用对大鼠痔疮模型和大鼠佐剂性关节炎模型的影响。结果威灵仙、棉团铁线莲、东北铁线莲不同剂量水煎液均能改善大鼠痔疮模型肛周溃疡症状,加速痔疮创面修复,促进愈合,减轻肛周肿胀;减轻大鼠关节炎模型足跖肿胀,改善关节肿胀及屈伸不利症状,降低血清炎症因子IL-1β,TNF-α水平。结论威灵仙可促进病理组织修复,加快溃疡面的愈合,具有抗炎功能。OBJECTIVE To summarize the external function of Clematidis Radix et Rhizoma through the experimental study of external use. METHODS Observed the effects of three varieties of Clematidis Radix et Rhizoma, water decoction for external use on rats model of hemorrhoid and rats adjuvant-induced arthritis model. RESULTS Water decoction of Clematis chinensis Osbeck, C. hexapetala Pall, C. manshurica Rupr. could improve rats model of hemorrhoid symptoms of perianal ulcers, accelerated wound healing, promote healing and reduce the perianal swelling, reduced arthritis in rats model of plantar foot swelling, improve joint swelling and motor impairment symptoms, reduced serum inflammatory factors in IL-1β, TNF-α level. CONCLUSION External use of Clematidis Radix et Rhizoma can repair pathological tissue, speed up the uleer area healing with anti-inflammatory fuction.

关 键 词：威灵仙 外用 痔疮 佐剂性关节炎 

分 类 号：R285.5[医药卫生—中药学]