“一测多评”测定木香顺气丸中木香内酯类成分  

Determination of Costuslactone in Muxiang Shunqi Pills By QAMS

作　　者：赖增发 夏丽珍[2] 

机构地区：[1]福建省三明市药品检验所,福建三明365000 [2]福建省三明市中西医结合医院,福建三明365001

出　　处：《中国现代应用药学》2014年第4期421-424,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立"一测多评"法测定木香顺气丸中2种木香内酯类成分的高效液相色谱分析方法,使之更有效的控制其质量。方法以木香烃内酯为内标,建立其与去氢木香内酯的相对校正因子,用高效液相色谱法进行含量测定,计算木香烃内酯、去氢木香内酯的含量,对"一测多评"法的计算值与外标法实测值进行比较。结果建立的相对校正因子重现性良好,采用相对校正因子计算的含量与外标法实测值无显著性差异。结论 "一测多评"法可用于木香顺气丸中木香内酯类成分的含量测定,方法可靠,结果准确,能有效控制该制剂质量。OBJECTIVE To establish a method for determinaion of two costuslactone in Muxiang Shunqi pills by quantitative analysis of multi-components by single marker（QAMS） for more perfect quality. METHODS Taking costunolide, as reference, a relative correction factor（RCF） of dehydrocostuslactone was established. Then the RCF was used to calculate the contents of the dehydrocostuslacton. In this way, the calculated value was compared with the external standard method. RESULTS No significant differences were found in the quantitative analysis results of dehydrocostuslacton between external standard method and QAMS method. CONCLUSION The described method is reliable, accurate, and can be used to control the quality of costuslactone of Muxiang Shunqi pills.

关 键 词：木香顺气丸 木香内酯 一测多评 HPLC 

分 类 号：R917.101[医药卫生—药物分析学]