甘草酸二铵治疗急性脑梗死60例疗效分析  

Efficacy of Diammonium Glycyrrhizinate in Treatment of Acute Cerebral Infarction

作　　者：杜守云 付怀栋[1] 

机构地区：[1]灌云县人民医院神经内科,江苏灌云222200

出　　处：《中国现代应用药学》2014年第4期486-489,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的观察甘草酸二铵治疗急性脑梗死的临床疗效。方法急性脑梗死患者120例,随机分为对照组和试验组,每组60例,2组患者均予以抗血小板聚集、他汀类药物、脑保护、改善循环、控制血压等常规神经内科治疗,试验组加用甘草酸二铵治疗,于入院第1,14,21天分别采用美国国立卫生院神经功能缺损评分(NIHSS)评价神经功能缺损程度,并测定超敏C反应蛋白(hs-CRP)的水平,评价疗效。结果试验组NIHSS评分、hs-CRP水平在第14,21天明显低于对照组,差异有统计学意义。试验组临床有效率(76.7%)显著高于对照组(60.0%),差异有统计学意义。结论甘草酸二铵能减轻脑梗死患者神经功能缺失症状,提高临床有效率,其机制可能与减轻炎症反应有关。OBJECTIVE To observe the effect of diammonium glycyrrhizinate in treatment of acute cerebral infarction. METHODS All of 120 patients with acute cerebral infarction were randomly divided into treatment group and control group. Patients in the two groups were given conventional neural medical treatment, including anti-platelet, statins, encephalic protection, improving cerebral circulation and controlling blood pressure, and patients in the treatment group were treated with diammonium glycyrrhizinate. NIHSS was used to evaluate defect of neurological function, and the contents of hs-CRP were detected to evaluate the curative effect. RESULTS Compared with control group, NIHSS and the contents of hs-CRP on the 14th, 21th day in treatment group decreased significantly. Clinical effective rate in treatment group（76.7%） was significantly higher than control group（60.0%）. CONCLUSION Diammonium glycyrrhizinate could reduce the neurological deficit in patients with cerebral infarction and improve the clinical efficacy. The mechanisms may be related to resultant alleviation of cerebral inflammatory.

关 键 词：脑梗死 甘草酸二铵 超敏C-反应蛋白 

分 类 号：R969.4[医药卫生—药理学]