D-二聚体、凝血指标、血小板参数检测对妊娠高血压疾病的应用价值分析  

The analysis on the value of the application of D-dimer,coagulation parameters,platelet parameters detection to the patients with hypertensive disorder complicating pregnancy

作　　者：廖丹[1] 

机构地区：[1]湖北科技学院附属第二医院妇产科,湖北咸宁437100

出　　处：《中国实验诊断学》2014年第4期621-624,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的观察和分析D-二聚体(D-D)、凝血指标、血小板参数检测对妊娠高血压疾病(HDCP)的应用价值。方法选取60例HDCP患者作为HDCP组,选取足月妊娠待产健康孕妇60例作为妊晚组,选取健康育龄非孕妇女60例作为对照组,对三组研究对象的D-D水平、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶凝结时间(TT)、纤维蛋白原(FIB)、血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)等指标进行检测和比较。结果 HDCP组的D-D水平显著高于妊晚组(P<0.05),妊晚组显著高于对照组(P<0.05);对照组的PT水平显著高于妊晚组(P<0.05),妊晚组显著高于HDCP组(P<0.05);妊晚组的APTT水平显著低于HDCP组和对照组(P均小于0.05);HDCP组的FIB水平显著高于妊晚组(P<0.05),妊晚组显著高于对照组(P<0.05);对照组的PLT水平和PCT水平均显著高于HDCP组和妊晚组(P均小于0.05),HDCP组的MPV水平和PDW水平均显著高于妊晚组和对照组(P均小于0.05);随着HDCP患者病情程度的加重,其D-D水平呈现显著升高的趋势(P均小于0.05)。结论 HDCP患者机体的高凝状态和继发性纤溶状态均显著高于正常孕妇和非妊娠妇女,血栓形成的趋势和危险性较高,且D-D水平与患者的病情可能存在正相关关系,联合应用D-D水平、凝血指标、血小板参数检测对患者进行监测对于HDCP的早期诊断和及时治疗具有重要的意义。Objective To observe and analyze the value of the application of D-dimer （D-D）,coagulation parame-ters,platelet parameters detection to the patients with hypertensive disorder complicating pregnancy （HDCP）.Methods 60 patients with HDCP were selected as the HDCP group,60 cases of healthy women with full-term pregnancy were selected as the late pregnancy group and 60 cases of healthy non pregnant women in childbearing age were selected as the control group.The D-D levels,prothrombin time （PT）,activated partial thromboplastin time （APTT）,thrombin condensation time （TT）,fibrinogen （FIB）,platelet count （PLT）,platelet hematocrit （PCT）,mean platelet volume （MPV）,platelet volume distribution width （PDW）of the subjects in the three groups were tested and compared.Re-sults The D-D level of the HDCP group was significantly higher than that of the late pregnancy group （P 〈0.05）and the level of the late pregnancy group was significantly higher than that of the control group （P 〈0.05）;The PT level of the control group was significantly higher than that of the late pregnancy group （P 〈0.05）and the level of the late pregnancy group was significantly higher than that of the HDCP group （P 〈0.05）;The APTT level of the late preg-nancy group was significantly lower than that of the HDCP group or the control group （Ps were all less than 0.05）;The FIB level of the HDCP group was significantly higher that of the late pregnancy group （P 〈0.05）and the level of the late pregnancy group was significantly higher than that of the control group （P 〈0.05）;The PLT level and PCT level of the control group were significantly higher than those of the HDCP group or the late pregnancy group （Ps were all less than 0.05）,while the MPV level and PDW level of the HDCP group were significantly higher than those of the late pregnancy group or the control group （P 〈0.05）;With the aggravation of HDCP,the D-D levels of the patients in-creased significantly （P 〈0.05�

关 键 词：D-二聚体 凝血指标 血小板参数 妊娠高血压疾病 

分 类 号：R714.246[医药卫生—妇产科学]