2-(苯甲基)-7-氯茚并[1,2-e][1,3,4]噁二嗪-2,4a(3H,5H)-二羧酸4a甲酯的合成  

Pratical Preparation of(+)4a-methyl-2-phenylmethyl-7-chloroindeno[1,2-e][1,3,4]oxadiazine-2,4a(3H,5H)di carboxylate

作　　者：卜洪忠[1] 吴晓伟[1] 李伟[1] 关建宁[1] 马鸿飞[1] 黄佳维 李玉峰[1] 

机构地区：[1]南京工业大学理学院,江苏南京211816

出　　处：《广东化工》2014年第7期6-7,共2页Guangdong Chemical Industry

摘　　要：以5-氯-1-茚酮为起始原料,经羰基化、不对称氧化、腙化和缩合反应合成了高效杀虫剂茚虫威的关键中间体2-(苯甲基)-7-氯茚并[1,2-e][1,3,4]噁二嗪-2,4a(3H,5H)-二羧酸4a甲酯。以5-氯-1-茚酮计,产品总收率达61.1%,产品结构经核磁共振分析验证。探讨了原料配比、溶剂的选择、氧化剂等因素对反应收率的影响。Using 5-chloro-l-indone as starting material, 4a-methy-2-phenyhnethy-7-chrinden[2-e][34]xadiazine-24a（3H5H）dicarbxyate was synthesized by carbonylation, asymmetric oxidation, hydrazone and condensation, in a total yield of 61.1%, which is a key intermediate of indoxacarb. The structure of product was confirmed by NMR analysis. The influence of the ratio of reactants, solvent selection and oxygenant on the yield was investigated.

关 键 词：2-(苯甲基)-7-氯茚并[1 2-e][1 3 4]噁二嗪-2 4a(3H 5H)-二羧酸4a-甲酯 5-氯-1-茚酮 茚虫威 合成 

分 类 号：TQ[化学工程]