多间距视网膜表面微电极阵列设计与特性测试  

Design and feature test of multi-distance epi-retinal microelectrode

作　　者：崔红岩[1] 郝玲玲[1] 陈俪行 胡勇[1] 徐圣普[1] 冯莉[1] 谢小波[1] 

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津300192 [2]香港城市大学生物医学工程系,香港999077

出　　处：《中国医学装备》2014年第4期1-4,共4页China Medical Equipment

基　　金：国家自然科学基金(81271667)"视网膜微电极植入动物体后受内环境电生理因素影响的仿真研究";天津市科技支撑计划重点项目(10zckfsy08400)"视网膜表面微电极阵列的研制和动物实验研究"

摘　　要：目的:为优化视网膜微电极阵列的设计而设计多间距电极阵列,并对其进行性能测试。方法:采用聚氯代二甲苯(parylene)柔性材料作为柔性衬底,以惰性金属Au作为电极材料,设计不同间距的单排电极阵列,并对微电极阵列的外观、机械性能和柔韧性进行测试。结果:经测试,微电极表面及边缘清晰,导线与电极之间连接完好,连线间无短路。柔韧性检测显示,微电极阵列的柔韧性满足下一步动物实验的要求。结论:设计完成的微电极阵列可为进一步的动物在体视网膜微电极实验提供可靠的条件。Objective：To optimize the design and fabrication of epi-retinal microelectrode array for the retain vision of RP and AD patients, multi-distance flexible electrode array was designed and fabricated. Electro-chemical feature test of the array was performed.Methods：Parylene with flexibility and biocompatibility was used as substrate material and Au was used as electrode material. Multi-distance microelectrode array was designed and fabricated, and then mechanical property and flexibility of the array were tested.Results： Mechanical property and flexible test results showed that the fabricated microelectrode array fulfilled the design requirement.Conclusion： The designed and fabricated array can be put into animal experiment for optimization design of the array by obtaining in vivo electro-physiological test results.

关 键 词：视网膜表面微电极阵列 视觉假体 优化设计 

分 类 号：R318.18[医药卫生—生物医学工程]