一种新型的HA载药系统药物释放度的测定  

Measurement of Dissolution Rate of a Novel Targeted Drug Delivery System Based on Hyaluronic Acid

作　　者：姜晓晔 吕海清[1] 刘永琼[1] 

机构地区：[1]武汉科技大学城市学院医学部,武汉430083

出　　处：《数理医药学杂志》2014年第2期193-195,共3页Journal of Mathematical Medicine

基　　金：武汉科技大学城市学院院级科研项目(编号2013CYYBKY003)

摘　　要：目的:设计一种新型的透明质酸(HA)靶向载药系统,为开发治疗卵巢癌的美法仑靶向制剂奠定基础。方法:用活化的聚乙二醇对HA进行修饰后作为载体,与抗肿瘤药美法仑键合形成前药,再自组装成纳米胶束给药系统,并用高效液相法(HPLC)测定药物在模拟人体环境条件下的释药情况。结果:pH值会显著影响药物的累计释放量,P<0.05;取样量对给药体系的累计释放量没有显著性影响,P>0.05。结论:pH影响透明质酸酶的活性,所以会对药物的释放度带来影响。而取样量的对释放度没有显著性影响。Objective：A novel targeted drug delivery system based on hyaluronic acid was constructed in this dissertation,which laid the foundation of melphalan targeting agents for the treatment of ovarian cancer. Methods：an anticancer prodrug was made by connected melphalan with polyethylene glycol （PEG）activated hyaluronic acid ,then self-assembled into nano-micelle.The release conditions in vitro was measured by HPLC.Results：the pH value affected the accumulative release amount significantly,P＆lt;0.05;while Sample Volume reflected no significant influence,P＆gt;0.05.Conclusion：the pH influenced the hyaluronidase activi-ty,then impacted the drug release while the amount of sampling showed no significant impact .

关 键 词：透明质酸 聚乙二醇 美法仑 胶束 释放度 

分 类 号：R969[医药卫生—药理学]