慢性肾纤维化机制的研究概况  

Research on Mechanism of Renal Interstitial Fibrosis

作　　者：饶杰[1] 吴金玉[2] 李昆英 胡溪[1] 江旖旎 黄小森 

机构地区：[1]广西中医药大学研究生学院,广西南宁53000 [2]广西中医药大学第一附属医院,广西南宁53000

出　　处：《辽宁中医杂志》2014年第4期826-828,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然基金(81060292)

摘　　要：肾脏纤维化(RIF)是所有慢性肾脏疾病发展至终末期肾脏病的最后共同通路,以正常肾单位的丢失、大量成纤维细胞及肌成纤维细胞的增生、细胞外基质的产生和堆积而导致肾小球硬化、肾小管间质纤维化等为特征。研究表明,肾小管上皮/内皮间充质细胞的转分化、物理因素以及多种化学因子的共同作用,在诱导、促进RIF过程中发挥重要作用。现就近年来关于RIF的发生、发展及主要的影响因素方面的进展作一概述。Renal interstitial fibrosis is a common consequence of all chronic kidney diseases which develop to the end stage renal disease. The pathological characteristics of renal interstitial fibrosis is glomerular sclerosis and renal interstitial fibrosis which are caused by the loss of normal renal units ,proliferation of fibroblast and myofibroblast ,production and accumulation of extracel- lular matrix. Studies show that the cooperative action of physical factors and kinds of chemokines besides epithelial mesenchymal transition play an important role in the process of inducing and mediating renal interstitial fibrosis. Here ,we reviewed the research progress in the development and the main influencing factors of renal interstitial fibrosis.

关 键 词：慢性肾纤维化 机制 综述 

分 类 号：R692[医药卫生—泌尿科学]