氨基酸螯合铁剂对34－37周早产儿贫血的防治作用  

Effect of amino acid chelated iron in prevention of anemia in preterm infant

作　　者：龙卉[1] 任锦霞[2] 衣京梅[1] 许琼[1] 

机构地区：[1]中国人民解放军总医院儿内科,北京100853 [2]北京朝阳医院儿内科,北京100020

出　　处：《中国医刊》2014年第4期45-47,共3页Chinese Journal of Medicine

摘　　要：目的探讨预防性补充氨基酸螯合铁剂对34周以上早产儿血红蛋白的影响。方法将75例34－37周早产儿随机分为三组。对照组不预防服用药物；低铁组生后2周至6个月口服甘氨酸螯合铁[铁元素1mg/（kg·d）]；高铁组生后2周至6个月口服甘氨酸螯合铁[铁元素2mg/（kg·d）]。观察血红蛋白变化情况及服药后反应。结果低铁组、高铁组贫血发生率与对照组比较差异均有显著性；低铁组、高铁组血红蛋白分别与对照组比较，自生后4个月差异均有显著性。结论34~37周早产儿生后2周至6个月服用甘氨酸螯合铁可预防出现贫血，但剂量增加未提高预防效果。Objective To explore the effect of amino acid chelated iron on hemoglobin level in premature infant whose gestational age was over 34 weeks. Method There were 75 preterm infants employed in our study who were ad-mitted to two hospitals from April 2010 through April 2011 for gestational age during 34 to 37 weeks. They were ran-domized divided into three groups. Group one（n=35）： no amino acid chelated iron was given,in other two groups （ n=20 for each group） ,infants were given amino acid chelated iron from 2 weeks old to six months,with iron ele-ment 1mg/（kg·d）,or 2mg/（kg·d） respectively. Hemoglobin level in blood had been recorded during the six months. Result 17 cases（48. 57%） had anemia symptom at four months in control group,4 cases in experimental group one and 1 case in experimental group two at five months. There was significance different hemoglobin level be-tween control group and experimental groups during 6 months（P＆lt;0. 05）. All cases in experimental group hadn＆#39;t got significant side effect. The different of hemoglobin between control group and experimental group had statistical sig-nificance after four months. Conclusion Premature infant（gestational age 34 to 37 weeks） would develop anemia symptom after four months in case of not taking iron after birth. Amino acid chelated iron is capable of prevention a-nemia in premature infant without significant side effect. The dosage of 2mg/（kg·d） could not get better prevention than dosage of 1mg/（kg·d）.

关 键 词：早产儿 贫血 氨基酸螯合铁 

分 类 号：R722.6[医药卫生—儿科]