定量抗环瓜氨酸肽抗体检测在早期类风湿关节炎诊断中的价值  

The value of anti-cyclic citrullinated peptide antibody quantitative testing in the diagnosis of early rheumatoid arthritis

作　　者：贾淑芳 袁璐 张蒙 陈启容 邓燕 熊力 匡红 曾琳 周琳瑶 

机构地区：[1]解放军第四五二医院检验科,成都610061

出　　处：《中国医师进修杂志》2014年第11期7-9,共3页Chinese Journal of Postgraduates of Medicine

基　　金：四川省卫生厅科学研究项目（100191）

摘　　要：目的 探讨定量抗环瓜氨酸肽（CCP）抗体检测在早期类风湿关节炎（RA）诊断中的临床意义.方法 选择2011年1-12月收治的120例RA患者作为试验组,另选取同期健康体检者120例作为对照组,定量检测其抗CCP抗体浓度,同时检测RA常用相关诊断指标[类风湿因子（RF）],对结果进行统计分析.结果 与对照组比较,试验组患者抗CCP抗体和RF浓度均明显升高[（5.9±1.4） RU/ml比（2.3±0.2）RU/ml、（41±18） kU/L比（28 ±9） kU/L],差异有统计学意义（P＜0.05）.病程在1年内的RA患者抗CCP抗体和RF的灵敏度分别为88.5％（54/61）和75.4％（46/61）,差异有统计学意义（P＜0.05）.以临床诊断结果为金标准,抗CCP抗体和RF的Kappa系数分别为0.81和0.63.结论 抗CCP抗体具有较高的灵敏度,综合临床表现,对早期RA的辅助诊断具有较好的指导意义.Objective To explore the clinical significance of anti-cyclic citrullinated peptide （anti-CCP） antibody quantitative testing in the diagnosis of early rheumatoid arthritis（RA）. Methods One hundred and twenty patients with RA from January to December 2011 were chosen as the experimental group and 120 cases with healthy check-up people in the same period were chosen as the control group, quantitative testing the anti-CCP antibody, while detecting RA related diagnosis index [rheumatoid factor （RF） ], the results were analyzed. Results Compared with control group, the level of anti-CCP antibody and RF in experimental group were significantly elevated [ （5.9 ± 1.4） RU/ml vs. （2.3 ± 0.2） RU/ml, （41 ± 18 ） kU/L vs.（28 ± 9 ） kU/L], there were significant differences （P 〈 0.05 ）. The sensitivity of anti-CCP antibody and RF within 1 year course of disease was 88.5% （54/61） and 75.4% （46/61）,there was significant difference （P 〈 0.05）. Clinical diagnosis as the gold standard,the Kappa of the anti-CCP antibody and RF was 0.81 and 0.63. Conclusion The anti-CCP antibody has high sensitivity,clinical manifestations, diagnosis of early RA has good guidance value.

关 键 词：类风湿因子 关节炎 类风湿 抗环瓜氨酸肽抗体 

分 类 号：R593.22[医药卫生—内科学]