大孔树脂吸附蝉蜕水提醇沉物有效组分的动力学研究  

Macroporous Resin Adsorption Kinetics for Effective Extraction of Water Extracting with Alcohol Precipitating in Cicada Slough

作　　者：何亮颖[1] 曹唯仪[1] 杜清华[1] 王玉蓉[1] 赵韶华 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]石家庄以岭医药集团,石家庄050035

出　　处：《世界科学技术-中医药现代化》2014年第3期554-559,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家"973"重点基础研究计划(2012CB518606):通络药物物质基础;作用机制及临床评价研究;负责人:吴以岭

摘　　要：目的:研究大孔树脂对蝉蜕水提醇沉物有效组分的静态吸附动力学特征。方法:以凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血凝-纤溶药效为主要筛选指标,通过静态吸附实验确定大孔树脂型号;以考马斯亮蓝为显色剂,检测并绘制吸附动力学曲线,确定NKA-9型树脂分离纯化蝉蜕有效组分的动力学模型。结果:NKA-9型树脂对蝉蜕水提醇沉物有效组分分离纯化能力最高,拟二级动力学方程可很好地描述吸附动力学过程。结论:吸附速率主要由颗粒内扩散控制。This article was aimed to study macroporous resin adsorption kinetics for effective extraction of water ex-tracting with alcohol precipitating in cicada slough. PT, APTY and the coagulation-fibrinolysis dynamic figure were taken as main indexes, which were combined with static and dynamic tests, to select the best macroporous resin to separate and purify the extraction. Adsorption kinetics curve was drawn to fit the adsorption kinetics model. The re- suits showed that NKA-9 macroporous resin was more effective in separating and purifying effective extraction than others. The adsorption dynamic behavior was well described by the pseudo-second-order kinetics equation. It was concluded that the adsorption rate was mainly controlled by the intraparticle diffusion.

关 键 词：大孔树脂 蝉蜕 水提醇沉物 凝血酶原时间 活化部分凝血活酶时间 血凝-纤溶 吸附动力学 

分 类 号：R285[医药卫生—中药学]