早期糖尿病肾病证候分布及影响因素的研究  

Research on Traditional Chinese Medicine Syndrome Distribution and Influential Factors of Early-stage Diabetic Nephropathy

作　　者：陈静[1] 曹峰[1] 李文[1] 刘继涛[2] 

机构地区：[1]贵阳中医学院基础医学院,贵阳550001 [2]贵阳中医学院研究生部,贵阳550001

出　　处：《世界科学技术-中医药现代化》2014年第3期649-653,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：贵州省科技厅贵阳中医学院联合基金项目(2010LKZ7016):早期糖尿病肾病防治的KY3H健康保障服务的理论及临床研究;负责人:陈静;贵州省中管局中医药民族医药科学技术研究课题(QZYY2010-09):运用中医"治未病"理论防治早期DN的KY3H健康保障服务的临床研究;负责人:陈静

摘　　要：目的:探讨早期糖尿病肾病(DN)患者中医证候与影响因素的相关性,为DN的防治提供理论依据。方法:选取符合西医诊断标准的早期DN样本,共236例,运用单因素和多元Logistic回归统计分析。结果:气阴两虚证的危险因素主要有体质量指数(BMI)、年龄、病程、冠心病、高血压、脉无力;阴虚燥热证的危险因素主要有吸烟,甘油三酯(TG)、尿微量白蛋白(UMA)升高,舌红、苔黄;脾肾气虚证的危险因素有苔白;瘀证的危险因素有TG、UMA升高,舌紫暗;痰瘀证的危险因素有苔黄燥、脉弦滑;湿热证的危险因素有运动情况、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)升高、苔黄厚。结论:早期DN中医证候之间存在一定的差异,临床辨证诊断及治疗应考虑上述因素的影响。This study was aimed to explore the relationship between traditional Chinese medicine （TCM） syndrome distribution characteristics and influential factors of early-stage diabetic nephropathy （DN） patients in order to pro- vide theoretical basis for DN prevention and treatment. A total of 236 early-stage DN cases were selected in con- sistency with western diagnostic criteria. The single-factor and multivariate logistic regression were used in the sta- tistical analysis. The results showed that the risk factors of qi-yin deficiency syndrome contained body mass index （BMI）, age, disease course, coronary heart disease （CHD）, hypertension, and weak pulse. Risk factors of yin-defi- ciency and dryness-heat syndrome contained smoking, TG and UMA elevation, red tongue with yellow coating. Risk factor of qi-deficiency of spleen and kidney syndrome contained white coating. Risk factors of stasis syndrome con-tained TG and UMA elevation, and dark purplish tongue. Risk factors of phlegm-stasis syndrome contained yellow and dryness coating, wiry and slippery pulse. Risk factors of damp-heat syndrome contained sports, TC, LDL-C el- evation, yellow and thick coating. It was concluded that there were some differences among TCM syndromes in the early-stage of DN. Therefore, the clinical syndrome diagnosis and treatment should consider influential factors men- tioned above.

关 键 词：早期糖尿病肾病 证候分布 影响因素 临床辨证 

分 类 号：R587.1[医药卫生—内分泌]