薄基底膜肾病超微结构观察与分析  

Ultrastructural observation and analysis of thin basement membrane nephropathy

作　　者：吴晓英[1] 朱小京[1] 张淑安[1] 曾珊[1] 

机构地区：[1]中南大学湘雅医学院基础电镜室,长沙410078

出　　处：《湖南医科大学学报》2001年第1期20-22,共3页Bulletin of Hunan Medical University

摘　　要：本文对 5例已确诊为薄基底膜肾病的活检标本进行回顾性观察 ,首次采用选择性定位测量法 ,测量基底膜厚度 ,并与临床表现相联系 ,以提高对此病的认识与诊断。结果表明 5例患者的肾小球基底膜厚度均 <2 5 0mm ,测量方法可靠。且基底膜厚度与血尿分级呈负相关 (r= 0 .39) ,与病程呈正相关 (r=0 .6 5 )。提示基底膜愈薄对红细胞的通透性愈大 ,而基底膜的广泛变薄可能是其发育不完善所致。In order to improve the diagnosis of thin basement membrane nephropathy, we observed the ultrastructure of renal biopsy specimens from five cases with thin basement membrane nephropathy, and selectively measured the thickness of the basement membrane. The result showed: ① The thickness of the basement membrane of five patients was less than 250?nm. ② The thickness of the basement membrane was positively related to the course of disease (r=0.65), While negatively related to the grade of haematuria (r=-0.39). The results suggest that hypoplasia may be the cause of extensively thinning of the basement membrane. [

关 键 词：超微结构 薄基底薄肾病 肾小球 活检 选择性定位测量法 

分 类 号：R692.7[医药卫生—泌尿科学]