痛风Ⅱ号中间体-2制备实验条件筛选  

Optimization of the experimental conditions of preparing the Gout Ⅱ intermediate-2 system

作　　者：王志宏[1] 张义梅[2] 廉冬雪[1] 张小东[1] 任方[1] 张天柱[1] 冯乾坤[1] 王艳华[1] 孟庆和[1] 王沛[1] 

机构地区：[1]长春中医药大学,长春130117 [2]吉林省中医药科学院,长春130021

出　　处：《长春中医药大学学报》2014年第2期211-212,共2页Journal of Changchun University of Chinese Medicine

基　　金：吉林省科技厅科技支撑项目(20120446)

摘　　要：目的优选痛风Ⅱ号中间体-2制备实验条件。方法选取痛风Ⅱ号中间体-2制得收率为评价指标,以正交试验法L9(34)优选制备实验条件参数。结果原料投料比为1∶1.2,反应温度为220℃,反应时间为2 h,酸洗量为1∶1.5。结论在所选因素水平范围内,原料投料比对本实验效果影响最大,所选条件制备工艺稳定,可行。Objective To optimize experimental conditions of preparing the goutⅡ intermediates-2. Methods The gout Ⅱ intermediates-2 yield was selected as evaluation index. The preparation of experiment conditions parameter was optimized by orthogonal test L9 （34）. Resdts The molar ratio of raw materials is 1 ： 1.2. The reaction temperature is 220℃. The reac- tion time is 2 hours. The amount of acid pickling is 1 ： 1.5. Conclusion The raw material ratio has the greatest impact on the experiment in the selected factors level range. The selected conditions of the preparation process are stable and feasible.

关 键 词：痛风Ⅱ号 制备工艺 正交设计 

分 类 号：R285.5[医药卫生—中药学]