肺癌骨转移机制研究  

A study on the mechanism of bone metastasis of lung cancer

作　　者：姜帆[1] 张帅[1] 王守东[1] 冯利[1] 

机构地区：[1]中国中医科学院望京医院肿瘤科,北京100102

出　　处：《长春中医药大学学报》2014年第2期344-346,共3页Journal of Changchun University of Chinese Medicine

基　　金：北京市自然科学基金资助项目(7122203)

摘　　要：骨是肺癌最常见的远处转移部位之一,骨转移一旦发生,会引起疼痛和运动障碍等并发症。实验证实,肿瘤靶器官产生的某些细胞因子(如细胞黏附分子、整合素等)与特异性受体相结合,在肿瘤细胞的脱离、外侵、趋化、迁移以及黏附过程中发挥重要作用。肺癌骨转移的机制与其临床病理学因素,肿瘤细胞与骨间质细胞之间的分子相关性,骨代谢相关的生化指标有着很大关系。肺癌骨转移的机制复杂,主要包括肺癌细胞离开原发病灶、进入淋巴系统和血液系统及远处生长等方面。Bone is one of the most common sites of metastases in lung cancer. If bone metastasis occurs, it causes pain and movement disorders and other complications. Studies have confirmed that cytokines produced by tumor target organs combine with its specific receptor）Cell adhesion molecules and integrin）. They play an important role in the process of detachment, invasion, migration, chemotaxis and adhesion. Mechanisms of lung cancer with bone metastasis have a very important rela- tionship with the clinical pathologic factors associated with bone memsmsis, the molecular correlation between tumor cells and bone mesenchymal cells. The mechanisms of bone metastasis of lung cancer are complex, including the leave of cancer cells from primary site to enter the lymphatic system and the blood system and remote growth and so on.

关 键 词：肺癌 骨转移 机制 细胞因子 

分 类 号：R273[医药卫生—中西医结合]