心肌梗塞大鼠心室胶原生化改建与心脏肾素-血管紧张素系统的关系  

Biochemical Remodeling of Myocardial Collagen and Its Relation to Cardiac Renin angiotensin System in Rats after Myocardial Infarction

作　　者：黄英[1] 雷立权[2] 高广道[2] 王树人[1] 孙晓明[2] 

机构地区：[1]华西医科大学基础医学院病理生理学教研室,成都610041 [2]西安交通大学基础医学院病理生理学教研室

出　　处：《华西医科大学学报》2001年第1期9-11,共3页Journal of West China University of Medical Sciences

基　　金：国家"八.五"攻关 !(批准号 85 -10 5 -0 3-0 2 );国家自然科学基金! (批准号 392 70 315 )资助项目

摘　　要：目的　研究心肌梗塞 ( MI)后心室胶原生化改建与心脏肾素 -血管紧张素系统 ( RAS)的关系。方法　采用放射免疫等方法动态观测了大鼠 MI后 3、15及 42天左、右心室胶原含量、总量和血管紧张素 ( Ang )含量以及血浆 Ang 含量的变化。结果　血浆 Ang 含量仅在 MI后 3天有一过性升高 ;MI鼠左、右心室 Ang 含量于 3天时就明显升高 ,此后一直保持在 3天时水平。 MI后左、右心室胶原基质均发生了生化改建 ,除右心室胶原生化改建稍滞后于其 Ang 的变化外 ,左、右心室的胶原生化改建与其心肌 Ang 的变化形式基本一致。结论　 MI后心脏 RAS被明显激活 ;心肌 Ang 在心肌胶原生化改建的过程中可能起着重要的作用 ,而且其作用不依赖于循环 RAS。Objective This study aimed at the biochemical rem odeling of myocardial collage n and its relation to cardiac renin angiotensin system (RAS) after myocardial i n farction(MI).Methods The ventricular and plasma angiotensin Ⅱ(Ang Ⅱ) content , total collagen content, and collagen concentration in left ventricle(LV) and right v entricle(RV) of MI and sham operated control(SOC) rats on 3,15 and 42 days afte r operation were measured dynamically by means of radioimmunoassay etc. Results The plasma Ang Ⅱ content increased only in MI rats on day 3. The Ang Ⅱ content in LV of the MI group increased markedly on day 3 after MI as compared with that of the SOC group.It sustained at this higher level on the 15 th and 42th days,and the similar changes were observed in RV as well.The biochem ical remodeling of collagen in LV and RV occurred after MI and the remodeling of collagen showed similar patterns with its Ang Ⅱ content, except that collagen remodeling in RV was delayed than the change of Ang Ⅱ content.Conclus ion The cardiac RAS was obviously activated after MI. Ventricular Ang Ⅱ mi ght play an important role in the biochemical remodeling of myocardial collagen, and its role was independent of circulating RAS.

关 键 词：心肌梗塞 心室胶原生化改建 心脏肾素-血管紧张素系统 大鼠 

分 类 号：R331.31[医药卫生—人体生理学]