北京市石景山区健康人群脊髓灰质炎的抗体水平  

Levels of poliovirus antibodies among healthy population in Shijingshan District of Beijing

作　　者：吴劲[1] 郭舫茹[1] 杨咸枝[1] 李敏[1] 杨娜[1] 任丽君[1] 何月莹[1] 刘斌[1] 

机构地区：[1]北京市石景山区疾病预防控制中心,100043

出　　处：《职业与健康》2014年第8期1072-1074,1077,共4页Occupation and Health

摘　　要：目的了解北京市石景山区健康人群脊髓灰质炎(简称脊灰)抗体水平,为制定各项卫生防病措施提供科学依据。方法采用随机抽样方法,对石景山区244名健康人群进行血标本采集,使用酶联免疫吸附试验检测脊灰中和抗体。结果Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为96.72%、95.90%和95.90%;几何平均滴度(GMT)分别为1∶84.06、1∶70.10和1∶57.12。不同性别、年龄、免疫史间抗体水平差异有统计学意义。不同户籍间抗体水平差异无统计学意义。结论石景山区健康人群脊灰抗体阳性率普遍较高,形成了有效的免疫屏障。[ Objective ] To understand the levels of poliovirus antibodies among healthy population in Shijingshan District of Beijing, provide scientific basis for developing the immunization strategy. [ Methods ] By the random sampling method, the blood samples were collected from 244 healthy people in Shijingshan District. The neutralizing antibodies against polioviruses were detected by the enzyme-linked immunosorbent assay. [ Results]The positive rate of neutralizing antibodies to poliovirus type I , I1 and m was re- spectively 96.72% , 95. 90% and 95.90% , while the geometric mean titer （ GMT} was respectively 1 ： 84.06, 1 ： 70.10 and 1 ： 57.12. There were significant differences in antibody levels among groups of different sex, age and immune history. The differ- ence in antibody levels between different household registration groups was not significant. [ Conclusion] The positive rates of anti- bodies against polioviruses among healthy population in Shijingshan District are high, and an effective immune barrier has been es- tablished.

关 键 词：脊髓灰质炎 中和抗体 阳性率 几何平均滴度 健康人群 

分 类 号：R181.81[医药卫生—流行病学]