参麦注射液治疗冠心病心绞痛临床疗效的系统评价  

Meta-analysis of Efficacy of Shenmai Injection Combined with Routine Therapy for Angina Pectoris

作　　者：郭胜才[1] 邹晓华[1] 邢旺兴[2] 谷娜[1] 

机构地区：[1]解放军第117医院,杭州310013 [2]杭州师范大学医药卫生管理学院

出　　处：《药物流行病学杂志》2014年第4期258-261,270,共5页Chinese Journal of Pharmacoepidemiology

基　　金：浙江省医学会临床科研基金项目(编号:2011ZYC-A42)

摘　　要：目的：系统评价中药制剂参麦注射液治疗冠心病心绞痛的临床疗效。方法： 计算机检索中文科技期刊全文数据库（CNKI）、中国医用信息资源系统（维普）、万方数据库、PubMed等数据库，检索时间均为1989～2012年。根据Cochrane系统评价方法对纳入的随机对照试验（RCT）进行质量评价，并应用RevMan5.1软件进行Meta分析。结果：共纳入8项研究，Meta分析结果表明，常规治疗联合参麦注射液与单纯常规治疗比较，在改善患者心绞痛症状和心电图异常方面差异均有统计学意义（P＜0.01），前者优于后者，其相对危险度RR及其95%CI分别为1.30（1.20，1.41）和1.36（1.21，1.52）。无严重不良反应报告。结论：目前临床证据支持参麦注射液结合常规治疗药物，在改善心绞痛的症状和心电图表现方面优于单纯西药常规治疗方法。由于纳入研究的数量少、质量不高，上述结论有待更多大样本、多中心且随访时间长的临床随机对照试验加以进一步验证。Objective：：To evaluate the efficacy and safty of Shenmai injection combined with conventional therapeutics for angina pectoris. Methods：CNKI, VIP, Wanfang Databases（during 1989 and 2012）, and PubMed were used to retrieve the data. The RevMan5.1 software was used to perform a meta analysis of included randomized controlled trials（RCTs）. Results：A total of 8 RCTs involved in 644 patients were included. The results of the meta analysis demonstrated that Shenmai injection combined with conventional therapy was superior to conventional therapy alone, and there was statistical difference in symptoms and electrocardiogram （ECG） improvements between the test and control group. The relative risk （RR） for efficacy and ECG improvements were 1.30（95%CI 1.20to 1.41） and 1.36（95%CI 1.21to 1.52）, espectively. Studies reporting adverse drug reaction（ADR） information showed that the symptoms of ADR were mild. Conclusion：The clincal evidences showed that Shenmai injection combined with conventional therapy was superior to the conventional therapy alone in the symptoms and ECG improvements for angina pectoris. Due to the small sample size and low quality of included studies, the conclusion needed to be further validated by more multicenter, randomized, double blind, controlled clincal trials, large sample size and adequate following up time

关 键 词：参麦注射液 冠心病心绞痛 META分析 

分 类 号：R286[医药卫生—中药学]