妊娠期妇女人细小病毒B19感染与死胎及胎儿畸形关系的研究  

The Relationship between maternal infection with human parvovirus B19 and fetal death and congenital malformation

作　　者：李冰琳[1] 屈新中[2] 王淑莉[1] 郭静[1] 

机构地区：[1]西安市中心医院妇产科,710003 [2]西安医科大学第一临床学院妇产科

出　　处：《中华妇产科杂志》2001年第1期24-26,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　了解妊娠期妇女人细小病毒B19(humanparvovirusB19,简称B19)感染与死胎及胎儿畸形的关系。方法　采用前瞻性的研究方法 ,应用聚合酶链反应 (PCR)技术对 335例孕妇血清进行B19DNA检测 ,并随访其妊娠结局。结果　在 335例孕妇中 ,血清B19DNA阳性 6 7例 ,B19DNA阴性 2 6 8例。其中在 6 7例B19DNA阳性者中 ,发生 4例死胎和 1例无脑儿 ,在 2 6 8例B19DNA阴性者中 ,无一例发生死胎和胎儿畸形 ,阳性与阴性者间比较 ,差异有显著性 (P <0 0 5 )。两者正常分娩的新生儿外观均无异常。Objective To study the relationship between matanal infection with human parvovirus B19 and fetal death and congenital malformation. Methed B19 DNA was detected by Polymerase Chain Reaction (PCR) in blood samples from 335 pregnant women. The pregnant outcomes were followed. Results In 335 pregnant women, 67 cases were B19 DNA positive and 268 cases were B19 DNA regative. There were four fetal deaths and one anencephalus in B19 DNA positive group. There was no fetal deaths or congenital malformation in B19 DNA negative group. The difference is significant ( P <0 05). Conclusions Maternal infection with human parvovirus B19 may contribute to fetal death and conge nital malformation.

关 键 词：人细小病毒B19 妊娠合并症 胎儿畸形 死胎 

分 类 号：R715.3[医药卫生—妇产科学]