氨溴索联合人免疫球蛋白静脉滴注治疗小儿重症肺炎的疗效观察  

Effect of ambroxol in combination with immune globulin in children with severe pneumonia

作　　者：黄葆莹[1] 何丽仪[1] 刘明伟[1] 罗昌寿[1] 

机构地区：[1]佛山市第一人民医院,佛山528000

出　　处：《新医学》2014年第3期198-200,共3页Journal of New Medicine

摘　　要：目的观察氨溴索联合人免疫球蛋白静脉滴注治疗小儿重症肺炎的疗效。方法选择153例重症肺炎患儿,随机分为对照组、单用组、联用组各51例,对照组予利巴韦林治疗,单用组在对照组基础上行氨溴索雾化吸入治疗,联用组在单用组基础上行静脉滴注人免疫球蛋白治疗。记录并比较3组患儿的疗效、症状缓解时间、住院时间、并发症发生情况。结果单用组和联用组的总有效率分别为84%、86%,均明显高于对照组的66%(P<0.017)。单用组和联用组的啰音消失、止咳、退热、平喘等症状缓解时间及住院时间均比对照组明显缩短(P<0.05)。联用组的并发症发生率明显低于对照组(P<0.017)。结论氨溴索联合人免疫球蛋白静脉滴注治疗小儿重症肺炎疗效良好,且安全性高。Objective To observe the effect of combined ambroxol and immune globulin treatment in children with severe pneumonia. Methods One hundred and fifty-three children with severe pneumonia were randomly divided into control group,single treatment group,and combination treatment group,each group contained 51 cases. Children in control group were given conventional ribavirin treatment,in single group were added with ambroxol,in combination group were given both immune globulin and ambroxol. The curative effect,symptom relief time,hospitalization time and complications occurrence of three groups were recorded and compared. Results The total effective rate in single group and combination group was 84%and 86%,re-spectively,which was significantly higher than that in control group （66%）（P＆lt;0.01 7）. Disappearance or relief of rale,cough,fever,and maintenance of asthma＆#39;s duration in single group and combination group were significantly better than those in control group （P＆lt;0.05 ）. In terms of complications,the total complications rate of combination group was significantly lower than that in control group （P＆lt;0.01 7）. Conclusion Ambr-oxol in combination with immune globulin is efficient and safe for children with severe pneumonia.

关 键 词：氨溴索 小儿重症肺炎 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]