血尿酸水平与帕金森病的相关性分析  

Correlation between serum uric acid level and Parkinson＇ s disease

作　　者：吴丹[1,2] 王林[2] 滕伟禹[1] 商秀丽[1] 

机构地区：[1]中国医科大学附属第一医院神经内科 [2]沈阳市红十字会医院神经内科

出　　处：《临床内科杂志》2014年第3期177-179,共3页Journal of Clinical Internal Medicine

基　　金：国家自然科学基金资助项目（81100243）;辽宁省博士科研启动基金资助项目（20101142）;辽宁省科技厅科学技术计划项目（2011225020）;辽宁省教育厅基金资助项目（L2013296）

摘　　要：目的 探讨血尿酸（UA）和帕金森病（PD）之间的关系.方法 收集116例PD组以及116例健康对照组的临床资料,分别应用简易智能精神状态量表（MMSE）及汉密尔顿抑郁量表（HAMD）评定其认知功能和抑郁程度.根据修订的Hoehn-Yahr （H-Y）分期将患者分为轻、中、重3组.对所有研究对象进行血尿酸水平的检测.结果 PD组患者的血尿酸水平明显低于健康对照组（P＜0.01）.PD组中有认知障碍及伴有抑郁者的血尿酸水平明显低于无认知障碍及不伴有抑郁者（P＜0.01）,轻、中、重3组患者间的血尿酸水平比较差异无统计学意义（P＞0.05）.MMSE评分与患者的血尿酸水平呈正相关,HAMD评分与患者的血尿酸水平呈负相关（P＜0.01）.结论 PD患者的血尿酸水平低于健康人群,并且与认知功能及抑郁密切相关.Objective To investigate the correlation between serum uric acid （UA） level and Parkinson＇ s disease（PD）. Methods The PD group of 116 patients with PD and the control group of 116 persons were recruited during the same period. The cognitive function and depression were assessed using the Mini-mental state examination（MMSE） and the Hamilton Depression Scale（HAMD） respectively. PD severity was assessed using the modified Hoehn-Yahr（H-Y） stage. The patients of PD group were divided into mild moderatand severe group based on the H-Y stage. The serum UA level of all study population were determined. Results The serum UA levels of the PD group were significantly lower than that of the control group（P 〈 0.01 ）. Within the PD group, the serum UA levels of the group with cognitive impair- ment or depression were lower than that of the group without cognitive impairment or depression （P 〈 0.01 ）. The serum UA levels of the mild, moderat and severe groups had no significant difference （P 〉 0.05）. MMSE score was positively correlated and HAMD score was negatively correlated with the serum UA levels of the PD patients （P 〈 0.01 ）. Conclusion The serum UA level of PD patients were lower than that of healthy people. It was closely correlated with the cognitive function and depression of PD patients.

关 键 词：帕金森病 血尿酸 认知功能障碍 抑郁 

分 类 号：R587.1[医药卫生—内分泌]