原发性高血压患者血内皮素与一氧化氮的变化及临床意义  

Change of plasm endothelin and nitric oxide and their clinic significance in patients with essential hypertension

作　　者：黄织春[1] 张莉[1] 刘凤琴[1] 郝富 

机构地区：[1]内蒙古医学院附属医院心内科,耳鼻咽喉科,内蒙古呼和浩特010050 [2]内蒙古自治区卫生厅,内蒙古呼和浩特010020

出　　处：《内蒙古医学杂志》2001年第1期7-10,共4页Inner Mongolia Medical Journal

摘　　要：目的 :探讨原发性高血压 (EH)患者血内皮素 (ET)、一氧化氮 (NO)的变化及与血压的关系。方法 :以放免法测血浆ET ,硝酸还原酶法测血清NO ,检测 30例正常人及 6 7例不同程度及临床分期的EH患者。结果 :EH组血浆ET水平明显高于对照组 (P <0 0 1 ) ,NO水平明显低于对照组 (P <0 0 1 ) ,NO/ET比值明显低于对照组(P <0 0 1 ) ,这种变化与病情严重程度平行。平均血压与ET呈正相关 ,与NO呈负相关。结论 :EH患者存在内皮细胞功能变化 ,血ET、NO的失衡参与EH的发生发展 ,测定血ET、NO水平对了解EH病情及指导治疗有一定意义。Objective:To investigate the relationship between the changes of plasm endothelin (ET) and nitric oxide (NO) and blood pressure in patients with essential hypertension (EH).Methods:30 normotensive controls (NC) and 67 EH patients in different stage were studied.Plasm ET were detected by radioimmunoassay (RIA) method and serum NO level by colorimeteric.Results:The plasm ET level in EH patients was higher and serum NO level was lower than those in NC groups (all P<0.01).NO/ET ratio was decreased in EH (P<0.01),there was significant difference between patients and NC.The change was correlated to the severity of disease.Mean artery pressure(MAP)is positively correlated with ET but negative correlated with NO.Conclusion:The patients with essential hypertension had a vascular endothelial dysfunction.The imbalance of ET and NO released by vascular endothelial cell may be the important causes of the hypertention.It might be served as an index to access the severity of disease and a basis for therapy.[

关 键 词：高血压 内皮素 一氧化氮 EH 

分 类 号：R544.102[医药卫生—心血管疾病]