不同酸碱条件下三种头孢菌素表面增强拉曼光谱的比较  

Comparison of Surface Enhanced Raman Spectrum for Three Cephalosporins under Different pH Conditions

作　　者：赵娟 张雁[1,2] 

机构地区：[1]湘潭市食品药品检验所,湖南湘潭411100 [2]中国食品药品检定研究院

出　　处：《中国药师》2014年第4期546-549,共4页China Pharmacist

基　　金：重大新药创制科技重大专项(编号:2011ZX09303-001)

摘　　要：目的:研究头孢氨苄、头孢羟氨苄及头孢拉定的拉曼光谱及表面增强拉曼光谱,对三种化合物在不同酸碱条件下的表面增强拉曼光谱进行分析。方法:用便携式拉曼光谱仪对三种物质的常规拉曼光谱与不同酸碱条件下的表面增强拉曼光谱进行考察。结果:研究表明,三种化合物均能在表面增强拉曼光谱中表现出跟常规拉曼光谱相对应的特征峰信息,酸碱度对于三种物质表面增强拉曼光谱的检测均有一定影响。结论:头孢氨苄、头孢羟氨苄及头孢拉定的拉曼光谱及表面增强拉曼光谱均体现出一定的指纹性特征,用拉曼光谱法鉴别这三种头孢类抗菌药是可行的。Objective：To study the Raman spectrum and the surface enhanced Raman spectrum （ SERS） of cefalexin, cefadroxil and cephradine, and analyze the surface enhanced Raman spectrum of the three compounds under different pH conditions. Methods：The Raman spectrum and the surface enhanced Raman spectrum of the three compounds under different pH conditions were detected and measured by a portable Raman spectroscopy. Results： The results showed that the three compounds could exhibit characteristic peak information in the surface enhanced Raman spectroscopy corresponding to that in the normal Raman spectrum, and the pH values had certain impact on the surface enhanced Raman spectrum of the three substances. Conclusion： Both the Raman spectrum and the surface enhanced Raman spectrum of cefalexin, cefadroxil and cephradine reflect certain fingerprint characteristics, and it is feasible to use Raman scattering method to identify the three cephalosporins.

关 键 词：拉曼光谱 表面增强拉曼光谱 不同酸碱条件 指纹性特征 鉴别 

分 类 号：R917[医药卫生—药物分析学]