孕妇胎盘组织中缺氧诱导因子HIF-1α的表达与子痫前期发病关系的Meta分析  

Relationship between hypoxia-inducible factor-1α in placenta and preeclampsia: a Meta-analysis

作　　者：张艳芳 田静 刘娜 李琳 蒋小青 

机构地区：[1]南京医科大学第一附属医院 [2]江苏省妇幼保健院保健部,江苏南京210036

出　　处：《现代医学》2014年第3期261-264,共4页Modern Medical Journal

摘　　要：目的:探讨孕妇胎盘缺氧诱导因子(HIF-1α)表达变化与子痫前期发病的关系。方法:以"HIF-1α、子痫前期(preeclampsia)"为检索词检索Medline、EMBase、PubMed数据库、中国生物医学文献数据库、万方数据库,收集HIF-1α与子痫前期发病关系的病例对照研究,筛选、评价文献并提取数据进行Meta分析。结果:共纳入6项研究,主要从病例组与对照组方法的选择、病例组与对照组的可比性、接触暴露评估方法 3个方面对文献进行评价。Meta分析结果表明,子痫前期组胎盘组织中HIF-1α表达水平高于正常妊娠组[OR=5.65,95%CI(3.42,9.33)]。结论:孕期HIF-1α的高表达与子痫前期的发病有关。Objective： To evaluate the relationship between preeclampsia. Methods： Through the term of hypoxia-inducible hypoxiainducible factorl a in factor-lot and preeclampsia to placenta and search a casecontrol study in which some cases about the relationship between hypoxia-inducible factor-la in placenta and preeclampsia were searched out from Medline, EMBase, PubMed, CBMdisc, Wanfang database to have the sifted, evaluated and extracted for Meta-analysis. Results： The author evaluated the six articles being involved in the case- control study finally from three aspects ： the selection nethods of case and control group used, comparability of the two groups, contact exposure assessment method. Meta-analysis indicated that there were statistical significance between hypoxiainducible factor- 1α in placenta and preeclampsia [ OR = 5. 65,95% CI （ 3. 42, 9.33 ） ]. Conclusion： There is significant correlation between hypoxia-inducible factor-1 α in placenta and development of preeclampsia.

关 键 词：胎盘组织 缺氧诱导因子-1α 子痫前期 META分析 

分 类 号：R714.245[医药卫生—妇产科学]