普伐他汀对鼠动脉粥样硬化及炎症因子的影响  

Effect of pravastatin on murine atherosclerosis and inflammatory factors

作　　者：郭水连[1] 卓晓青[2] 刘建立[3] 万荣 李双宏[3] 吕孝欣[3] 田艳[1] 马建亮[3] 

机构地区：[1]山东省潍坊医学院,261053 [2]山东大学附属省立医院,250021 [3]山东省潍坊医学院附属医院心内科,261031 [4]山东省枣庄矿业集团中心医院心内科,277011

出　　处：《临床合理用药杂志》2014年第11期11-12,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的研究普伐他汀对鼠动脉粥样硬化形成过程及炎症因子的影响。方法取40只大鼠制作动脉粥样硬化模型,随机分为正常饮食组(A)、对照组(B)、普伐他汀(C,10mg·kg-1·d-1)、普伐他汀(D,20mg·kg-1·d-1)各10只。B、C、D组定期腹腔注射维生素D破坏内皮细胞,喂养3个月,抽血检测hs-CRP,IL-6,并解剖大鼠制作病理切片,最后处死所有大鼠。结果 B组病理切片显示内膜明显增厚,管壁弥漫性隆起,内皮下含大量泡沫细胞,中膜平滑肌细胞增生。而A组内膜光滑,内皮下未见泡沫细胞,中膜平滑肌排列整齐有序,未见增生改变,C、D组内膜增生情况较B组轻,较A组重,且C组较D组增生明显。炎症因子hs-CRP,IL-6在B、C、D、A中的检测水平依次下降,B组较A组、B组较C组、B组较D组、C组较D组差异均有统计学意义(P<0.05)。结论普伐他汀有降低炎症因子,抑制动脉粥样硬化形成的作用。Objective To study the effect of pravastatin on murine atherosclerosis formation process and inflammatory factors. Methods 40 rats were made into the model of atherosclerosis and divided into normal diet group （ A）, control group （ B）, pravastatin 10mg· kg-1 . d - 1 （ C ）, pravastatin 20mg· kg- 1 . d -1 （ D ）, each Of 10 casses. The group B, group C and group D were injected vitamin D regularly to damage endothelial cells, all the rats were fed for 3 months. The hs-CRP and IL- 6 were detected by blood testing. The rats were dissected and made into pathological section, and finally they were killed. Re- suits The pathological section of group B revealed that the tunica intima was thickening obviously,the pipe wall showed dif- fuse uplift, there was a large amount of foam cells in endothelial cells, and the smooth muscle cell was proliferating. However, the endomembrane of group A is smooth, there were no foam cells in endothelial cells, and the smooth muscle is neat and order- ly, with no proliferative changes. The intimal hyperplasia situation of group C and D was lighter than group B, and heavier than group A, and group C was heavier than group D. The inflammatory cytokines hs-CRP, IL-6 in group B, C, D and A was descend- ing in turn, the group B compared with group A, group B compared with group C, group B compared with group D , group C compared with group D, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The pravastatin can reduce in- flammatory cytokines and inhibit atherosclerosis formation.

关 键 词：普伐他汀 动脉粥样硬化 hs-CRP IL-6 

分 类 号：R541.4[医药卫生—心血管疾病]