喷雾型与皮下注射型麻疹减毒活疫苗血清学效果比较的Meta分析  

Comparison on serological effect of aerosolized measles vaccine and subcutaneous measles vaccine： a meta -analysis

作　　者：胡昱[1] 陈雅萍[1] 唐学雯[1] 沈灵智[1] 郭静[1] 

机构地区：[1]浙江省疾病预防控制中心免疫规划所,杭州310051

出　　处：《国际流行病学传染病学杂志》2014年第2期104-108,共5页International Journal of Epidemiology and Infectious Disease

摘　　要：目的 比较喷雾型麻疹减毒活疫苗（AMV）和皮下注射型麻疹减毒活疫苗（SMV）接种后抗体阳转率，评价血清学效果。方法检索美国国家医学图书馆数据库和Cochrane协作网图书馆等数据库，将研究接种AMV和SMV后比较血清学效果的随机对照实验（RCT）和前瞻性对照研究（PS）的文献全部纳入分析，用RevMan5．1进行分析。结果共纳入9篇文献，6篇为RCT研究，3篇PS研究，共纳入研究对象2549名（AMV组l289名、SMV组1060名）。总体上AMV抗体阳转率与SMV差异无统计学意义（OR=O．91，95％CI：0.36～2．31，P〉0.05）；6篇RCT文献合并后，AMV抗体阳转率与SMV差异无统计学意义（OR=I．32，95％CI：0．43-4．01，Z=0．49，P〉0．05）；4-18月龄儿童AMV抗体阳转率是SMV的17％（DR=0．17，95％CI：0．04～0．70，P〈0．01）；5—14岁组AMV抗体阳转率是SMV的3．45倍（OR=3．45，95％Chl．62~7．35，P〈0．01）。结论AMV与SMV的血清学效果无明显差异，小年龄组中SMV接种后血清学效果高于AMV，而大年龄组中AMV接种后血清学效果高于SMV。Objective To compare the different seroconversion rates after vaccination of aerosolized measles vaccine （AMV） and subcutaneous measles vaccine （SMV）. Methods National Center for Biotechnology Information （NCBI） and Cochrane Library databases were searched to retrieve all randomized controlled trials （RCT） or controlled prospective study （PS） on comparison of serological effect （SE） after vaccination of AMV and SMV. Statistical analysis was performed by RevMan5.1 software. Results Nine studies （6 RCT documents and 3 PS documents） were selected, including 2 349 subjects enrolled in the study （n=1 289 in AMV group, n=l 060 in SMV group）. No significant difference was found in seroconversion rate after AMV compared to SMV （OR=0.91, 95% CI： 0.36-2.31, P〉0.05）. In 6 RCT designs, no statistically difference was noted in seroconversion rate between AMV and SMV （OR=1.32, 95% CI： 0.43-4.01, Z=0.49, P〉0.05）. The seroconversion rate of AMV was 0.17 times lower than that of SMV among children aged 4-18 months （OR=0.17, 95%CI： 0.04-0.70, P〈0.01）,but 3.45 times higher than that of SMV among children aged 5-14 years （OR=3.45, 95%CI： 1.62-7.35, P〈0.01）. Conclusions The AMV has serological effect as good as SMV, and AMV appears to have more immunogenicity than SMV does in children under the age of 2 years.

关 键 词：疫苗 麻疹 血清学效果 META分析 

分 类 号：R186[医药卫生—流行病学]