不同来源天然骨磷灰石的材料学性能比较研究  

Comparative Studies on the Material Performances of Natural Bone-like Apatite from Different Bone Sources

作　　者：樊晓霞[1] 任浩浩[1] 陈抒天[1] 王广妮[1] 邓天煜[1] 陈星陶 严永刚[1] 

机构地区：[1]四川大学物理科学与技术学院,成都610064

出　　处：《生物医学工程学杂志》2014年第2期352-356,共5页Journal of Biomedical Engineering

基　　金：国家支撑科技计划项目资助(2007BAE13B00);生物材料与临床产品四川省青年科技创新研究团队项目资助(2011JTD0024)

摘　　要：以人骨、牛骨、猪骨和羊骨组织为原材料,在测试原骨组织抗压强度后,于800℃煅烧8h,除去有机成分及其相应的抗原性,形成不同来源的骨磷灰石。通过组成和结构测试,并比较人骨组织形成的磷灰石与其它三种动物骨组织形成的磷灰石的组成和结构差别,确定哪种动物骨组织获得的磷灰石更接近于人骨磷灰石、在材料学性能上更适合作为人体修复和替代材料。结果表明,羊骨的抗压强度与人骨密质骨抗压强度接近,为(135.00±7.84)MPa。傅里叶变换红外光谱(FT-IR)、X-射线衍射(XRD)分析结果表明,羊骨磷灰石和人骨磷灰石具有更接近的结构和物相组成;电感耦合等离子谱(ICP)测试结果表明,羊骨磷灰石中的微量元素与人骨磷灰石更为接近;能量弥散谱(EDS)测试结果表明,羊骨磷灰石和人骨磷灰石的Ca/P值最为接近,为1.73±0.033;扫描电镜(SEM)分析结果表明,羊骨磷灰石与人骨磷灰石具有更接近的微观形貌。研究显示,羊骨与人骨具有更接近的抗压强度、煅烧后的羊骨磷灰石无机组成成分与形貌和人骨磷灰石相似,在材料学性能方面煅烧后的羊骨磷灰石更适合作为潜在的无机生物陶瓷材料。The compressive strength of the original bone tissue was tested, based on the raw human thigh bone, bo- vine bone,pig bone and goat bone. The four different bone-like apatites were prepared by calcining the raw bones at 800℃ for 8 hours to remove organic components. The comparison of composition and structure of bone-like apatite from different bone sources was carried out with a composition and structure test. The results indicated that the com- pressive strength of goat bone was similar to that of human thigh hone, reached （135.00±7.84） MPa; Infrared spectrum （IR）, X-ray diffraction （XRD） analysis results showed that the bone-like apatite from goat bone was much closer to the structure and phase composition of bone-like apatite of human bones. Inductively Coupled Plasma （ICP） test results showed that the content of trace elements of bone-like apatite from goat bone was closer to that of apatite of human bone. Energy Dispersive Spectrometer （EDS） results showed that the Ca/P value of bone-like apatite from goat bone was also close to that of human bone, ranged to 1.73±0. 033. Scanning electron microscopy （SEM） pat- terns indicated that the macrographs of the apatite from human bone and that of goat bone were much similar to each other. Considering all the results above, it could be concluded that the goat bone-like apatite is much similar to that of human bone. It can be used as a potential natural bioceramic material in terms of material properties.

关 键 词：原骨组织 煅烧 骨磷灰石 组成和结构 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程]