猪皮寡肽对大鼠皮肤创面bFGF的影响  

Effect of Zhupiguatai on bFGF in Rat Skin Wound Healing

作　　者：吕旭潇[1] 孙明江[1] 刘长龙[1] 代龙[1] 

机构地区：[1]山东中医药大学药理学系,济南250355

出　　处：《医学研究杂志》2014年第4期29-32,共4页Journal of Medical Research

基　　金：国家"十一五"科技支撑计划项目(2008BAI53B073);山东省自然科学基金资助项目(ZR2011HM051)

摘　　要：目的探讨猪皮寡肽对碱性成纤维细胞生长因子(bFGF)的影响。方法建立大鼠皮肤创伤模型。随机分为5组:模型组、阳性对照组(京万红组)、猪皮寡肽高剂量组(相当于2倍临床浓度剂量)、猪皮寡肽中剂量组(相当于常规人用剂量)、猪皮寡肽低剂量组(相当于0.5倍临床浓度剂量)。取用药后第7、14天局部创面新生肉芽组织为所需实验样品,观察猪皮寡肽对皮肤创面碱性成纤维细胞生长因子的影响。结果第7天高剂量组中bFGF含量高于其他组,第14天组织中各组bFGF含量下降,但猪皮寡肽高、中剂量组明显高于其他各组。结论猪皮寡肽能够提高创面愈合过程中bFGF的含量。Objective To investigate the effect of Zhupiguatai on bFGF.Methods After the models beingset up,the rats were randomly assigned to 5 groups：model group,Jing wan hong group,the high does of Zhupiguatai group,the medium dose of Zhupiguatai group,and the low dose of Zhupiguatai group.The 7,14days granulation tissue was taken to be as the desired experiment samples.The effect of Zhupiguatai on the bFGF was observed.Results bFGF of first 7 days in the high dose group were higher than that in other groups.Levels of bFGF decreased in each tissue of The first 14 days.But it in Zhupiguatai high dose group was significantly higher than that in other groups.Conclusion Zhupiguatai can improve bFGF levels in wound healing process.

关 键 词：猪皮寡肽 创面愈合 BFGF 免疫组化 

分 类 号：R318[医药卫生—生物医学工程]